Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes
An interagency collaboration was established to model chemical interactions that may cause adverse health effects when an exposure to a mixture of chemicals occurs. Many of these chemicals—drugs, pesticides, and environmental pollutants—interact at the level of metabolic biotransformations mediated...
Main Authors: | Richard D. Beger, Eugene Demchuk, Bruce A. Fowler, Dan A. Buzatu, Jon G. Wilkes, Weida Tong, James C. Fuscoe, Luis G. Valerio, Huixiao Hong, Weigong Ge, Laura K. Schnackenberg, Bruce A. Pearce, Yunfeng Tie, Brooks McPhail |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2012-03-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/17/3/3383/ |
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