Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of premature aging but have a reduced incidence of canc...
Main Authors: | Jung Yoon Park, Mi-Ook Cho, Shanique Leonard, Brent Calder, I Saira Mian, Woo Ho Kim, Susan Wijnhoven, Harry van Steeg, James Mitchell, Gijsbertus T J van der Horst, Jan Hoeijmakers, Pinchas Cohen, Jan Vijg, Yousin Suh |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-06-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2396506?pdf=render |
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