Impact of Insulin Receptor Substrate‐1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention

Impact of Insulin Receptor Substrate‐1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention

Background Insulin receptor substrate‐1 (IRS‐1) rs956115 is associated with vascular risk in patients with coronary artery disease and concomitant diabetes. CYP2C19*2 (rs4244285) modulates clopidogrel response and predicts the outcome of coronary artery disease. This study was designed to explore th...

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Bibliographic Details
Main Authors: Jiaxin Zong, Yingdan Tang, Tong Wang, Inam Ullah, Ke Xu, Jing Wang, Pengsheng Chen, Zengguang Chen, Tiantian Zhu, Jun Chen, Jimin Li, Fei Wang, Lu Yang, Yuansheng Fan, Lu Shi, Xiaoxuan Gong, John W. Eikelboom, Yang Zhao, Chunjian Li
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
coronary artery disease
CYP2C19 rs4244285
IRS‐1 rs956115
percutaneous coronary intervention
platelet reactivity
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.025058

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