Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse
The objective of this study was to determine the diagnostic ability of serum amyloid A (SAA) and fibrinogen for early detection of surgical site infection (SSI) after equine internal fixation. Horses undergoing internal fixation for fracture, arthrodesis, or osteotomy with internal fixation for limb...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.960865/full |
| _version_ | 1811241895891828736 |
|---|---|
| author | Catherine C. Thurston Darko Stefanovski Melissa C. MacKinnon Hannah-Sophie Chapman Dean W. Richardson David G. Levine |
| author_facet | Catherine C. Thurston Darko Stefanovski Melissa C. MacKinnon Hannah-Sophie Chapman Dean W. Richardson David G. Levine |
| author_sort | Catherine C. Thurston |
| collection | DOAJ |
| description | The objective of this study was to determine the diagnostic ability of serum amyloid A (SAA) and fibrinogen for early detection of surgical site infection (SSI) after equine internal fixation. Horses undergoing internal fixation for fracture, arthrodesis, or osteotomy with internal fixation for limb deformity were included in the study. SAA and fibrinogen were measured on blood samples preoperatively and on days 1, 3, 5, 7, 10, and 14 postoperatively. Statistical analysis included use of Spearman's rank correlation, logistic regression, and calculating the area under the receiver operating characteristic (ROC) curve. SAA and fibrinogen measurements were both associated with SSI, with SAA being considered an excellent marker (area under the ROC curve 0.8) and fibrinogen being considered acceptable (<0.8). As the amount of time postoperatively increased, SAA elevations indicated a higher likelihood of SSI (area under the ROC curve 0.8 compared with fibrinogen 0.7). SAA and fibrinogen were predictive markers of SSI and SAA is of greater diagnostic utility when compared with fibrinogen. Persistent elevations of SAA postoperatively are associated with the development of SSI. Serial monitoring of SAA can be used to help predict the development of SSI in horses undergoing internal fixation. This may lead to earlier suspicion, and therefore recognition and treatment of SSI. |
| first_indexed | 2024-04-12T13:43:09Z |
| format | Article |
| id | doaj.art-8f1371adc266499aba0c5beda703ea0c |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T13:43:09Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-8f1371adc266499aba0c5beda703ea0c2022-12-22T03:30:47ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-10-01910.3389/fvets.2022.960865960865Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horseCatherine C. Thurston0Darko Stefanovski1Melissa C. MacKinnon2Hannah-Sophie Chapman3Dean W. Richardson4David G. Levine5New Bolton Center, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, United StatesNew Bolton Center, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, United StatesDepartment of Population Medicine, University of Waterloo, Waterloo, ON, CanadaPferdeklinik Leichlingen, Leichlingen, GermanyNew Bolton Center, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, United StatesNew Bolton Center, Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA, United StatesThe objective of this study was to determine the diagnostic ability of serum amyloid A (SAA) and fibrinogen for early detection of surgical site infection (SSI) after equine internal fixation. Horses undergoing internal fixation for fracture, arthrodesis, or osteotomy with internal fixation for limb deformity were included in the study. SAA and fibrinogen were measured on blood samples preoperatively and on days 1, 3, 5, 7, 10, and 14 postoperatively. Statistical analysis included use of Spearman's rank correlation, logistic regression, and calculating the area under the receiver operating characteristic (ROC) curve. SAA and fibrinogen measurements were both associated with SSI, with SAA being considered an excellent marker (area under the ROC curve 0.8) and fibrinogen being considered acceptable (<0.8). As the amount of time postoperatively increased, SAA elevations indicated a higher likelihood of SSI (area under the ROC curve 0.8 compared with fibrinogen 0.7). SAA and fibrinogen were predictive markers of SSI and SAA is of greater diagnostic utility when compared with fibrinogen. Persistent elevations of SAA postoperatively are associated with the development of SSI. Serial monitoring of SAA can be used to help predict the development of SSI in horses undergoing internal fixation. This may lead to earlier suspicion, and therefore recognition and treatment of SSI.https://www.frontiersin.org/articles/10.3389/fvets.2022.960865/fullserum amyloid Apostoperative infectionfibrinogensurgical site infectionequine surgeryinternal fixation |
| spellingShingle | Catherine C. Thurston Darko Stefanovski Melissa C. MacKinnon Hannah-Sophie Chapman Dean W. Richardson David G. Levine Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse Frontiers in Veterinary Science serum amyloid A postoperative infection fibrinogen surgical site infection equine surgery internal fixation |
| title | Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| title_full | Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| title_fullStr | Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| title_full_unstemmed | Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| title_short | Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| title_sort | serum amyloid a and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse |
| topic | serum amyloid A postoperative infection fibrinogen surgical site infection equine surgery internal fixation |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.960865/full |
| work_keys_str_mv | AT catherinecthurston serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse AT darkostefanovski serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse AT melissacmackinnon serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse AT hannahsophiechapman serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse AT deanwrichardson serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse AT davidglevine serumamyloidaandfibrinogenasmarkersforearlydetectionofsurgicalsiteinfectionassociatedwithinternalfixationinthehorse |