Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery
Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and biocompatibility. This mini-review focuses on various ways to synthesize polypeptides, as well as on their biomedical applications as anti-tumor drug carriers over the past five years. Var...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5042 |
| _version_ | 1797504432848502784 |
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| author | Huayang Feng Jonas Fabrizi Jingguo Li Christian Mayer |
| author_facet | Huayang Feng Jonas Fabrizi Jingguo Li Christian Mayer |
| author_sort | Huayang Feng |
| collection | DOAJ |
| description | Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and biocompatibility. This mini-review focuses on various ways to synthesize polypeptides, as well as on their biomedical applications as anti-tumor drug carriers over the past five years. Various approaches to preparing polypeptides are summarized, including solid phase peptide synthesis, recombinant DNA techniques, and the polymerization of activated amino acid monomers. More details on the polymerization of specifically activated amino acid monomers, such as amino acid N-carboxyanhydrides (NCAs), amino acid N-thiocarboxyanhydrides (NTAs), and N-phenoxycarbonyl amino acids (NPCs), are introduced. Some stimuli-responsive polypeptide-based drug delivery systems that can undergo different transitions, including stability, surface, and size transition, to realize a better anti-tumor effect, are elaborated upon. Finally, the challenges and opportunities in this field are briefly discussed. |
| first_indexed | 2024-03-10T04:04:29Z |
| format | Article |
| id | doaj.art-8f1401b098be44719ec8a91577e82caf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:04:29Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8f1401b098be44719ec8a91577e82caf2023-11-23T08:26:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239504210.3390/ijms23095042Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug DeliveryHuayang Feng0Jonas Fabrizi1Jingguo Li2Christian Mayer3Institute for Physical Chemistry, CeNIDE, University of Duisburg-Essen, 45141 Essen, GermanyInstitute for Physical Chemistry, CeNIDE, University of Duisburg-Essen, 45141 Essen, GermanyPeople’s Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450003, ChinaInstitute for Physical Chemistry, CeNIDE, University of Duisburg-Essen, 45141 Essen, GermanyPolypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and biocompatibility. This mini-review focuses on various ways to synthesize polypeptides, as well as on their biomedical applications as anti-tumor drug carriers over the past five years. Various approaches to preparing polypeptides are summarized, including solid phase peptide synthesis, recombinant DNA techniques, and the polymerization of activated amino acid monomers. More details on the polymerization of specifically activated amino acid monomers, such as amino acid N-carboxyanhydrides (NCAs), amino acid N-thiocarboxyanhydrides (NTAs), and N-phenoxycarbonyl amino acids (NPCs), are introduced. Some stimuli-responsive polypeptide-based drug delivery systems that can undergo different transitions, including stability, surface, and size transition, to realize a better anti-tumor effect, are elaborated upon. Finally, the challenges and opportunities in this field are briefly discussed.https://www.mdpi.com/1422-0067/23/9/5042polypeptide synthesisactivated amino acid monomersdrug deliverynanocarrierscancer treatment |
| spellingShingle | Huayang Feng Jonas Fabrizi Jingguo Li Christian Mayer Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery International Journal of Molecular Sciences polypeptide synthesis activated amino acid monomers drug delivery nanocarriers cancer treatment |
| title | Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery |
| title_full | Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery |
| title_fullStr | Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery |
| title_full_unstemmed | Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery |
| title_short | Syntheses of Polypeptides and Their Biomedical Application for Anti-Tumor Drug Delivery |
| title_sort | syntheses of polypeptides and their biomedical application for anti tumor drug delivery |
| topic | polypeptide synthesis activated amino acid monomers drug delivery nanocarriers cancer treatment |
| url | https://www.mdpi.com/1422-0067/23/9/5042 |
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