Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性)
合成了以喹诺酮药物分子(诺氟沙星、氧氟沙星和环丙沙星)为配体的钆(Ⅲ)配合物Gd(L)3·6H2O(L为药物配体).通过红外光谱、摩尔电导率、元素分析和顺磁共振等方法对配合物进行了表征,推测了配合物的可能结构,并用液体稀释法测定了药物配体和配合物对2种革兰氏阳性菌和2种革兰氏阴性菌的体外抑制活性,结果表明配合物与药物配体的抗菌活性和抗菌谱相同;采用MTT比色法测定了配体及配合物对HL-60(人急性早幼粒白血病)细胞的抑制作用,采用SRB蛋白染色法测定了配体及配合物对BEL-7402(人肝细胞性肝癌)细胞的抑制作用,结果表明Gd(OFLX)3·6H2O对BEL-7402细胞有强效抑制作用,Gd(...
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| Format: | Article |
| Language: | zho |
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Zhejiang University Press
2003-07-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/zjup/1008-9497.2003.30.4.417-421 |
| _version_ | 1797236383605063680 |
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| author | WANGGuo-ping(王国平) LEIQun-fang(雷群芳) |
| author_facet | WANGGuo-ping(王国平) LEIQun-fang(雷群芳) |
| author_sort | WANGGuo-ping(王国平) |
| collection | DOAJ |
| description | 合成了以喹诺酮药物分子(诺氟沙星、氧氟沙星和环丙沙星)为配体的钆(Ⅲ)配合物Gd(L)3·6H2O(L为药物配体).通过红外光谱、摩尔电导率、元素分析和顺磁共振等方法对配合物进行了表征,推测了配合物的可能结构,并用液体稀释法测定了药物配体和配合物对2种革兰氏阳性菌和2种革兰氏阴性菌的体外抑制活性,结果表明配合物与药物配体的抗菌活性和抗菌谱相同;采用MTT比色法测定了配体及配合物对HL-60(人急性早幼粒白血病)细胞的抑制作用,采用SRB蛋白染色法测定了配体及配合物对BEL-7402(人肝细胞性肝癌)细胞的抑制作用,结果表明Gd(OFLX)3·6H2O对BEL-7402细胞有强效抑制作用,Gd(CPLX)3·6H2O对HL-60和BEL-7402细胞均有强效抑制作用. |
| first_indexed | 2024-04-24T17:02:59Z |
| format | Article |
| id | doaj.art-8f14cd0705d3447aa9bb2b1b8ed8e244 |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T17:02:59Z |
| publishDate | 2003-07-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-8f14cd0705d3447aa9bb2b1b8ed8e2442024-03-29T01:58:20ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972003-07-01304417421zjup/1008-9497.2003.30.4.417-421Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性)WANGGuo-ping(王国平)0LEIQun-fang(雷群芳)1Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)合成了以喹诺酮药物分子(诺氟沙星、氧氟沙星和环丙沙星)为配体的钆(Ⅲ)配合物Gd(L)3·6H2O(L为药物配体).通过红外光谱、摩尔电导率、元素分析和顺磁共振等方法对配合物进行了表征,推测了配合物的可能结构,并用液体稀释法测定了药物配体和配合物对2种革兰氏阳性菌和2种革兰氏阴性菌的体外抑制活性,结果表明配合物与药物配体的抗菌活性和抗菌谱相同;采用MTT比色法测定了配体及配合物对HL-60(人急性早幼粒白血病)细胞的抑制作用,采用SRB蛋白染色法测定了配体及配合物对BEL-7402(人肝细胞性肝癌)细胞的抑制作用,结果表明Gd(OFLX)3·6H2O对BEL-7402细胞有强效抑制作用,Gd(CPLX)3·6H2O对HL-60和BEL-7402细胞均有强效抑制作用.https://doi.org/zjup/1008-9497.2003.30.4.417-421钆配合物喹诺酮合成抗菌活性抗肿瘤活性 |
| spellingShingle | WANGGuo-ping(王国平) LEIQun-fang(雷群芳) Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) Zhejiang Daxue xuebao. Lixue ban 钆配合物 喹诺酮 合成 抗菌活性 抗肿瘤活性 |
| title | Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) |
| title_full | Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) |
| title_fullStr | Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) |
| title_full_unstemmed | Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) |
| title_short | Synthesis, characterization, antibacterial and antitumor activities of three gadolinium (Ⅲ) complexes containing fluoroquinolones(钆(Ⅲ)-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性) |
| title_sort | synthesis characterization antibacterial and antitumor activities of three gadolinium iii complexes containing fluoroquinolones 钆 iii 喹诺酮配合物的合成 抗菌活性与抗肿瘤活性 |
| topic | 钆配合物 喹诺酮 合成 抗菌活性 抗肿瘤活性 |
| url | https://doi.org/zjup/1008-9497.2003.30.4.417-421 |
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