A Synthetic Formula Amino Acid Diet Leads to Microbiome Dysbiosis, Reduced Colon Length, Inflammation, and Altered Locomotor Activity in C57BL/6J Mice

A Synthetic Formula Amino Acid Diet Leads to Microbiome Dysbiosis, Reduced Colon Length, Inflammation, and Altered Locomotor Activity in C57BL/6J Mice

The effects of synthetic, free-amino acid diets, similar to those prescribed as supplements for (phenylketonuria) PKU patients, on gut microbiota and overall health are not well understood. In the current, multidisciplinary study, we examined the effects of a synthetically-derived, low-fiber, amino...

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Bibliographic Details
Main Authors: Viviana J. Mancilla, Paige N. Braden-Kuhle, Kelly N. Brice, Allison E. Mann, Megan T. Williams, Yan Zhang, Michael J. Chumley, Robert C. Barber, Sabrina N. White, Gary W. Boehm, Michael S. Allen
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Microorganisms
Subjects:
SCFA
inflammation
mouse model
fiber
synthetic diet
gut-brain axis
Online Access:https://www.mdpi.com/2076-2607/11/11/2694

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