Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure
One main disadvantage of commercially available allogenic bone substitute materials is the altered mechanical behavior due to applied material processing, including sterilization methods like thermal processing or gamma irradiation. The use of high hydrostatic pressure (HHP) might be a gentle altern...
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MDPI AG
2021-02-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/5/1069 |
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| author | Janine Waletzko-Hellwig Michael Saemann Marko Schulze Bernhard Frerich Rainer Bader Michael Dau |
| author_facet | Janine Waletzko-Hellwig Michael Saemann Marko Schulze Bernhard Frerich Rainer Bader Michael Dau |
| author_sort | Janine Waletzko-Hellwig |
| collection | DOAJ |
| description | One main disadvantage of commercially available allogenic bone substitute materials is the altered mechanical behavior due to applied material processing, including sterilization methods like thermal processing or gamma irradiation. The use of high hydrostatic pressure (HHP) might be a gentle alternative to avoid mechanical alteration. Therefore, we compressed ground trabecular human bone to granules and, afterwards, treated them with 250 and 300 MPa for 20 and 30 min respectively. We characterized the formed bone granule cylinders (BGC) with respect to their biomechanical properties by evaluating stiffness and stress at 15% strain. Furthermore, the stiffness and yield strength of HHP-treated and native human trabecular bone cylinders (TBC) as control were evaluated. The mechanical properties of native vs. HHP-treated TBCs as well as HHP-treated vs. untreated BGCs did not differ, independent of the applied HHP magnitude and duration. Our study suggests HHP treatment as a suitable alternative to current processing techniques for allogenic bone substitutes since no negative effects on mechanical properties occurred. |
| first_indexed | 2024-03-09T00:32:37Z |
| format | Article |
| id | doaj.art-8f1628815c9846cbb998ae658bf6bb78 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T00:32:37Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-8f1628815c9846cbb998ae658bf6bb782023-12-11T18:26:37ZengMDPI AGMaterials1996-19442021-02-01145106910.3390/ma14051069Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic PressureJanine Waletzko-Hellwig0Michael Saemann1Marko Schulze2Bernhard Frerich3Rainer Bader4Michael Dau5Department of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, GermanyBiomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Anatomy Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, GermanyBiomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, GermanyOne main disadvantage of commercially available allogenic bone substitute materials is the altered mechanical behavior due to applied material processing, including sterilization methods like thermal processing or gamma irradiation. The use of high hydrostatic pressure (HHP) might be a gentle alternative to avoid mechanical alteration. Therefore, we compressed ground trabecular human bone to granules and, afterwards, treated them with 250 and 300 MPa for 20 and 30 min respectively. We characterized the formed bone granule cylinders (BGC) with respect to their biomechanical properties by evaluating stiffness and stress at 15% strain. Furthermore, the stiffness and yield strength of HHP-treated and native human trabecular bone cylinders (TBC) as control were evaluated. The mechanical properties of native vs. HHP-treated TBCs as well as HHP-treated vs. untreated BGCs did not differ, independent of the applied HHP magnitude and duration. Our study suggests HHP treatment as a suitable alternative to current processing techniques for allogenic bone substitutes since no negative effects on mechanical properties occurred.https://www.mdpi.com/1996-1944/14/5/1069high hydrostatic pressuremechanical characterizationuniaxial compression testbone substitutesallograftbone regeneration |
| spellingShingle | Janine Waletzko-Hellwig Michael Saemann Marko Schulze Bernhard Frerich Rainer Bader Michael Dau Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure Materials high hydrostatic pressure mechanical characterization uniaxial compression test bone substitutes allograft bone regeneration |
| title | Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure |
| title_full | Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure |
| title_fullStr | Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure |
| title_full_unstemmed | Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure |
| title_short | Mechanical Characterization of Human Trabecular and Formed Granulate Bone Cylinders Processed by High Hydrostatic Pressure |
| title_sort | mechanical characterization of human trabecular and formed granulate bone cylinders processed by high hydrostatic pressure |
| topic | high hydrostatic pressure mechanical characterization uniaxial compression test bone substitutes allograft bone regeneration |
| url | https://www.mdpi.com/1996-1944/14/5/1069 |
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