Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer’s disease

Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer’s disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases and neuroinflammation. The optimal compoun...

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Hlavní autoři: Chuanyu Yu, Xueyan Liu, Bingxiang Ma, Jiexin Xu, Yiquan Chen, Chaoxian Dai, Huaping Peng, Daijun Zha
Médium: Článek
Jazyk:English
Vydáno: Taylor & Francis Group 2024-12-01
Edice:Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:
On-line přístup:https://www.tandfonline.com/doi/10.1080/14756366.2024.2313682