Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer’s disease

Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer’s disease

Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer’s disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against cholinesterases and neuroinflammation. The optimal compoun...

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Bibliografiska uppgifter
Huvudupphovsmän: Chuanyu Yu, Xueyan Liu, Bingxiang Ma, Jiexin Xu, Yiquan Chen, Chaoxian Dai, Huaping Peng, Daijun Zha
Materialtyp: Artikel
Språk:English
Publicerad: Taylor & Francis Group 2024-12-01
Serie:Journal of Enzyme Inhibition and Medicinal Chemistry
Ämnen:
Alzheimer’s disease
butyrylcholinesterase inhibitors
anti-neuroinflammation
pyranone-carbamate derivatives
cognitive improvement
Länkar:https://www.tandfonline.com/doi/10.1080/14756366.2024.2313682

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2024.2313682

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