Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience
Introduction: Patients with diabetes mellitus commonly develop chronic vascular complications including diabetic nephropathy (DN). Chronic inflammation plays an important role in pathogenesis of diabetes and its complications. Neutrophil-Lymphocyte Ratio (NLR) is a novel potential marker for determi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Dr. NTR University of Health Sciences |
| Subjects: | |
| Online Access: | http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2021;volume=10;issue=2;spage=82;epage=87;aulast=Rahar |
| _version_ | 1818965874559680512 |
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| author | Seema Rahar Sadhna Marwah Bindu Kulshreshtha |
| author_facet | Seema Rahar Sadhna Marwah Bindu Kulshreshtha |
| author_sort | Seema Rahar |
| collection | DOAJ |
| description | Introduction: Patients with diabetes mellitus commonly develop chronic vascular complications including diabetic nephropathy (DN). Chronic inflammation plays an important role in pathogenesis of diabetes and its complications. Neutrophil-Lymphocyte Ratio (NLR) is a novel potential marker for determining inflammation.
Objective: To study NLR in type 2 diabetes mellitus and its correlation with renal function.
Method: This study is a cross-sectional observational study conducted at a tertiary care hospital. This study included 200 patients diagnosed with type 2 diabetes mellitus, 100 of whom had deranged renal functions and 100 patients had normal renal function. The control group was composed of 100 healthy age and sex-matched subjects. NLR was calculated and statistical analysis was made using student's t-test, post HOC test, and ANOVA. A value of P < 0.05 was considered significant.
Results: When NLR was compared among three groups, NLR was significantly higher in diabetic patients as compared to controls and NLR was significantly higher in diabetic nephropathy group as compared to the diabetic with normal renal function group and control group.
Conclusions: NLR is a novel, simple and inexpensive marker that can be used as a measure of systemic inflammation in diabetes and correlates with severity of diabetic nephropathy. |
| first_indexed | 2024-12-20T13:23:56Z |
| format | Article |
| id | doaj.art-8f1abfca5d8e4e908e4c7dde1fed8f28 |
| institution | Directory Open Access Journal |
| issn | 2277-8632 |
| language | English |
| last_indexed | 2024-12-20T13:23:56Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dr. NTR University of Health Sciences |
| spelling | doaj.art-8f1abfca5d8e4e908e4c7dde1fed8f282022-12-21T19:39:19ZengWolters Kluwer Medknow PublicationsJournal of Dr. NTR University of Health Sciences2277-86322021-01-01102828710.4103/jdrntruhs.jdrntruhs_88_21Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experienceSeema RaharSadhna MarwahBindu KulshreshthaIntroduction: Patients with diabetes mellitus commonly develop chronic vascular complications including diabetic nephropathy (DN). Chronic inflammation plays an important role in pathogenesis of diabetes and its complications. Neutrophil-Lymphocyte Ratio (NLR) is a novel potential marker for determining inflammation. Objective: To study NLR in type 2 diabetes mellitus and its correlation with renal function. Method: This study is a cross-sectional observational study conducted at a tertiary care hospital. This study included 200 patients diagnosed with type 2 diabetes mellitus, 100 of whom had deranged renal functions and 100 patients had normal renal function. The control group was composed of 100 healthy age and sex-matched subjects. NLR was calculated and statistical analysis was made using student's t-test, post HOC test, and ANOVA. A value of P < 0.05 was considered significant. Results: When NLR was compared among three groups, NLR was significantly higher in diabetic patients as compared to controls and NLR was significantly higher in diabetic nephropathy group as compared to the diabetic with normal renal function group and control group. Conclusions: NLR is a novel, simple and inexpensive marker that can be used as a measure of systemic inflammation in diabetes and correlates with severity of diabetic nephropathy.http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2021;volume=10;issue=2;spage=82;epage=87;aulast=Rahardiabetes mellitusdiabetic nephropathyinflammationneutrophil- lymphocyte ratio |
| spellingShingle | Seema Rahar Sadhna Marwah Bindu Kulshreshtha Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience Journal of Dr. NTR University of Health Sciences diabetes mellitus diabetic nephropathy inflammation neutrophil- lymphocyte ratio |
| title | Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience |
| title_full | Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience |
| title_fullStr | Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience |
| title_full_unstemmed | Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience |
| title_short | Neutrophil lymphocyte ratio (NLR) in type 2 diabetes mellitus and its correlation with renal function: An institutional experience |
| title_sort | neutrophil lymphocyte ratio nlr in type 2 diabetes mellitus and its correlation with renal function an institutional experience |
| topic | diabetes mellitus diabetic nephropathy inflammation neutrophil- lymphocyte ratio |
| url | http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2021;volume=10;issue=2;spage=82;epage=87;aulast=Rahar |
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