Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview
Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating immune cells, endothelial cells, non-parenchyma...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/11/1339 |
| _version_ | 1797714105600049152 |
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| author | Daphne Pinheiro Isabelle Dias Karina Ribeiro Silva Ana Carolina Stumbo Alessandra Thole Erika Cortez Lais de Carvalho Ralf Weiskirchen Simone Carvalho |
| author_facet | Daphne Pinheiro Isabelle Dias Karina Ribeiro Silva Ana Carolina Stumbo Alessandra Thole Erika Cortez Lais de Carvalho Ralf Weiskirchen Simone Carvalho |
| author_sort | Daphne Pinheiro |
| collection | DOAJ |
| description | Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating immune cells, endothelial cells, non-parenchymal hepatic stellate cells, and fibroblasts, which become activated and lead to excessive extracellular matrix accumulation. The ongoing development of liver fibrosis results in a clinically silent and progressive loss of hepatocyte function, demanding the constant need for liver transplantation in clinical practice, and motivating the search for other treatments as the chances of obtaining compatible viable livers become scarcer. Although initially cell therapy has emerged as a plausible alternative to organ transplantation, many factors still challenge the establishment of this technique as a main or even additional therapeutic tool. Herein, the authors discuss the most recent advances and point out the corners and some controversies over several protocols and models that have shown promising results as potential candidates for cell therapy for liver fibrosis, presenting the respective mechanisms proposed for liver regeneration in each case. |
| first_indexed | 2024-03-12T07:47:00Z |
| format | Article |
| id | doaj.art-8f1b041b102a43f680d4e6d85f1147d8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:47:00Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8f1b041b102a43f680d4e6d85f1147d82023-09-02T20:53:18ZengMDPI AGCells2073-44092019-10-01811133910.3390/cells8111339cells8111339Mechanisms Underlying Cell Therapy in Liver Fibrosis: An OverviewDaphne Pinheiro0Isabelle Dias1Karina Ribeiro Silva2Ana Carolina Stumbo3Alessandra Thole4Erika Cortez5Lais de Carvalho6Ralf Weiskirchen7Simone Carvalho8Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, D-52074 Aachen, GermanyLaboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, BrazilFibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating immune cells, endothelial cells, non-parenchymal hepatic stellate cells, and fibroblasts, which become activated and lead to excessive extracellular matrix accumulation. The ongoing development of liver fibrosis results in a clinically silent and progressive loss of hepatocyte function, demanding the constant need for liver transplantation in clinical practice, and motivating the search for other treatments as the chances of obtaining compatible viable livers become scarcer. Although initially cell therapy has emerged as a plausible alternative to organ transplantation, many factors still challenge the establishment of this technique as a main or even additional therapeutic tool. Herein, the authors discuss the most recent advances and point out the corners and some controversies over several protocols and models that have shown promising results as potential candidates for cell therapy for liver fibrosis, presenting the respective mechanisms proposed for liver regeneration in each case.https://www.mdpi.com/2073-4409/8/11/1339liver fibrosiscell therapystem cellsprogenitor cellshepatocytessecretomein vitro |
| spellingShingle | Daphne Pinheiro Isabelle Dias Karina Ribeiro Silva Ana Carolina Stumbo Alessandra Thole Erika Cortez Lais de Carvalho Ralf Weiskirchen Simone Carvalho Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview Cells liver fibrosis cell therapy stem cells progenitor cells hepatocytes secretome in vitro |
| title | Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview |
| title_full | Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview |
| title_fullStr | Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview |
| title_full_unstemmed | Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview |
| title_short | Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview |
| title_sort | mechanisms underlying cell therapy in liver fibrosis an overview |
| topic | liver fibrosis cell therapy stem cells progenitor cells hepatocytes secretome in vitro |
| url | https://www.mdpi.com/2073-4409/8/11/1339 |
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