Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724
Objective: The purpose of this study was to explore the risk factors for Ocular metastasis (OM) of Gastric cancer (GC). Methods: This is a retrospective cohort study. A total of 1165 patients with GC were enrolled in this study and divided into OM and non-ocular metastasis (NOM) groups. Chi-square a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-01-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338211065876 |
| _version_ | 1798016418821701632 |
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| author | Wen-Qing Shi Shi-Nan Wu Tie Sun Hui-Ye Shu Qi-Chen Yang Qiu-Yu Li Ting Su Yi-Cong Pan Rong-Bin Liang Yi Shao |
| author_facet | Wen-Qing Shi Shi-Nan Wu Tie Sun Hui-Ye Shu Qi-Chen Yang Qiu-Yu Li Ting Su Yi-Cong Pan Rong-Bin Liang Yi Shao |
| author_sort | Wen-Qing Shi |
| collection | DOAJ |
| description | Objective: The purpose of this study was to explore the risk factors for Ocular metastasis (OM) of Gastric cancer (GC). Methods: This is a retrospective cohort study. A total of 1165 patients with GC were enrolled in this study and divided into OM and non-ocular metastasis (NOM) groups. Chi-square and independent samples t tests were used to determine whether differences in demographic characteristics and serological indicators (SI) between the two groups were significant. In addition, binary logistic regression was used to analyze the value of various SI as risk factors for OM in patients with GC. The statistical threshold was set as P < .05. Finally, receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value of various SI in differentiating the occurrence of OM in patients with GC. Results: The incidence of OM in older adults with GC was 1.1%. Adenocarcinoma was the most common type of GC in both groups, and there was no significant difference in demographic characteristics between the groups. Low-density lipoprotein (LDL), carbohydrate antigen-724 (CA724), and carcinoembryonic antigen levels were significantly higher in the OM group than the NOM group, while those of apolipoprotein A1 (ApoA1) were significantly lower in the OM than the NOM group. Binary logistic analysis showed that LDL, ApoA1, and CA724 were independent risk factors for OM in patients with GC ( P < .001, P = .033, and P = .008, respectively). ROC curve analysis generated area under the curve (AUC) values of 0.881, 0.576, and 0.906 for LDL, ApoA1, and CA724, respectively. In addition, combined analysis of LDL, ApoA1, and CA724 generated the highest AUC value of 0.924 ( P < .001). Conclusion: Among SI, LDL, ApoA1, and CA724 have predictive value for the occurrence of OM in GC, with the three factors combined having the highest value. |
| first_indexed | 2024-04-11T15:50:28Z |
| format | Article |
| id | doaj.art-8f1b72a12ffd49b0ab7c5f2597f784be |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-11T15:50:28Z |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-8f1b72a12ffd49b0ab7c5f2597f784be2022-12-22T04:15:19ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-01-012110.1177/15330338211065876Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724Wen-Qing Shi0Shi-Nan Wu1Tie Sun2Hui-Ye Shu3Qi-Chen Yang4Qiu-Yu Li5Ting Su6Yi-Cong Pan7Rong-Bin Liang8Yi Shao9 , Shanghai, China , Nanchang, People's Republic of China , Nanchang, People's Republic of China , Nanchang, People's Republic of China , Chengdu, People's Republic of China , Nanchang, People's Republic of China Massachusetts Eye and Ear, Medical School, Boston, MA, USA , Nanchang, People's Republic of China , Nanchang, People's Republic of China , Nanchang, People's Republic of ChinaObjective: The purpose of this study was to explore the risk factors for Ocular metastasis (OM) of Gastric cancer (GC). Methods: This is a retrospective cohort study. A total of 1165 patients with GC were enrolled in this study and divided into OM and non-ocular metastasis (NOM) groups. Chi-square and independent samples t tests were used to determine whether differences in demographic characteristics and serological indicators (SI) between the two groups were significant. In addition, binary logistic regression was used to analyze the value of various SI as risk factors for OM in patients with GC. The statistical threshold was set as P < .05. Finally, receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value of various SI in differentiating the occurrence of OM in patients with GC. Results: The incidence of OM in older adults with GC was 1.1%. Adenocarcinoma was the most common type of GC in both groups, and there was no significant difference in demographic characteristics between the groups. Low-density lipoprotein (LDL), carbohydrate antigen-724 (CA724), and carcinoembryonic antigen levels were significantly higher in the OM group than the NOM group, while those of apolipoprotein A1 (ApoA1) were significantly lower in the OM than the NOM group. Binary logistic analysis showed that LDL, ApoA1, and CA724 were independent risk factors for OM in patients with GC ( P < .001, P = .033, and P = .008, respectively). ROC curve analysis generated area under the curve (AUC) values of 0.881, 0.576, and 0.906 for LDL, ApoA1, and CA724, respectively. In addition, combined analysis of LDL, ApoA1, and CA724 generated the highest AUC value of 0.924 ( P < .001). Conclusion: Among SI, LDL, ApoA1, and CA724 have predictive value for the occurrence of OM in GC, with the three factors combined having the highest value.https://doi.org/10.1177/15330338211065876 |
| spellingShingle | Wen-Qing Shi Shi-Nan Wu Tie Sun Hui-Ye Shu Qi-Chen Yang Qiu-Yu Li Ting Su Yi-Cong Pan Rong-Bin Liang Yi Shao Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 Technology in Cancer Research & Treatment |
| title | Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 |
| title_full | Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 |
| title_fullStr | Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 |
| title_full_unstemmed | Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 |
| title_short | Risk Factors to Predict Ocular Metastasis in Older Adult Patients With Gastric Cancer:LDL, ApoA1, and CA724 |
| title_sort | risk factors to predict ocular metastasis in older adult patients with gastric cancer ldl apoa1 and ca724 |
| url | https://doi.org/10.1177/15330338211065876 |
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