<sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging
In this study, we evaluated the use of 15-(4-<sup>123</sup>I-iodophenyl)-3(R,S)-methylpentadecanoic acid (<sup>123</sup>I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that <sup>123</sup>I-BMIPP, which is used for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/1008 |
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| author | Yuka Muranaka Asuka Mizutani Masato Kobayashi Koya Nakamoto Miki Matsue Fumika Takagi Kenichi Okazaki Kodai Nishi Kana Yamazaki Ryuichi Nishii Naoto Shikano Shigefumi Okamoto Hideki Maki Keiichi Kawai |
| author_facet | Yuka Muranaka Asuka Mizutani Masato Kobayashi Koya Nakamoto Miki Matsue Fumika Takagi Kenichi Okazaki Kodai Nishi Kana Yamazaki Ryuichi Nishii Naoto Shikano Shigefumi Okamoto Hideki Maki Keiichi Kawai |
| author_sort | Yuka Muranaka |
| collection | DOAJ |
| description | In this study, we evaluated the use of 15-(4-<sup>123</sup>I-iodophenyl)-3(R,S)-methylpentadecanoic acid (<sup>123</sup>I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that <sup>123</sup>I-BMIPP, which is used for fatty acid metabolism scintigraphy in Japan, accumulated markedly in <i>Escherichia coli</i> EC-14 similar to <sup>18</sup>F-FDG, which has previously been studied for bacterial imaging. To elucidate the underlying mechanism, we evaluated changes in <sup>123</sup>I-BMIPP accumulation under low-temperature conditions and in the presence of a CD36 inhibitor. The uptake of <sup>123</sup>I-BMIPP by EC-14 was mediated via the CD36-like fatty-acid-transporting membrane protein and accumulated by fatty acid metabolism. In model mice infected with EC-14, the biological distribution and whole-body imaging were assessed using <sup>123</sup>I-BMIPP and <sup>18</sup>F-FDG. The <sup>123</sup>I-BMIPP biodistribution study showed that, 8 h after infection, the ratio of <sup>123</sup>I-BMIPP accumulated in infected muscle to that in control muscle was 1.31 at 60 min after <sup>123</sup>I-BMIPP injection. In whole-body imaging 1.5 h after <sup>123</sup>I-BMIPP administration and 9.5 h after infection, infected muscle exhibited a 1.33-times higher contrast than non-infected muscle. Thus, <sup>123</sup>I-BMIPP shows potential for visualizing fatty acid metabolism of bacteria for imaging bacterial infections. |
| first_indexed | 2024-03-10T03:06:43Z |
| format | Article |
| id | doaj.art-8f1cbb17a549428799f5fe5ae7bfc748 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:06:43Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8f1cbb17a549428799f5fe5ae7bfc7482023-11-23T12:38:05ZengMDPI AGPharmaceutics1999-49232022-05-01145100810.3390/pharmaceutics14051008<sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection ImagingYuka Muranaka0Asuka Mizutani1Masato Kobayashi2Koya Nakamoto3Miki Matsue4Fumika Takagi5Kenichi Okazaki6Kodai Nishi7Kana Yamazaki8Ryuichi Nishii9Naoto Shikano10Shigefumi Okamoto11Hideki Maki12Keiichi Kawai13Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanFaculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanFaculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanDivision of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanIshikawa Prefectural Institute of Public Health and Environmental Science, 1-11, Taiyogaoka, Kanazawa 920-1154, JapanLaboratory for Drug Discovery & Disease Research, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka 561-0825, JapanLaboratory for Drug Discovery & Disease Research, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka 561-0825, JapanDepartment of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage, Chiba 263-8555, JapanDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage, Chiba 263-8555, JapanDepartment of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, 4669-2 Ami, Inashiki 300-0394, JapanFaculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanLaboratory for Drug Discovery & Disease Research, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka 561-0825, JapanDivision of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, JapanIn this study, we evaluated the use of 15-(4-<sup>123</sup>I-iodophenyl)-3(R,S)-methylpentadecanoic acid (<sup>123</sup>I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that <sup>123</sup>I-BMIPP, which is used for fatty acid metabolism scintigraphy in Japan, accumulated markedly in <i>Escherichia coli</i> EC-14 similar to <sup>18</sup>F-FDG, which has previously been studied for bacterial imaging. To elucidate the underlying mechanism, we evaluated changes in <sup>123</sup>I-BMIPP accumulation under low-temperature conditions and in the presence of a CD36 inhibitor. The uptake of <sup>123</sup>I-BMIPP by EC-14 was mediated via the CD36-like fatty-acid-transporting membrane protein and accumulated by fatty acid metabolism. In model mice infected with EC-14, the biological distribution and whole-body imaging were assessed using <sup>123</sup>I-BMIPP and <sup>18</sup>F-FDG. The <sup>123</sup>I-BMIPP biodistribution study showed that, 8 h after infection, the ratio of <sup>123</sup>I-BMIPP accumulated in infected muscle to that in control muscle was 1.31 at 60 min after <sup>123</sup>I-BMIPP injection. In whole-body imaging 1.5 h after <sup>123</sup>I-BMIPP administration and 9.5 h after infection, infected muscle exhibited a 1.33-times higher contrast than non-infected muscle. Thus, <sup>123</sup>I-BMIPP shows potential for visualizing fatty acid metabolism of bacteria for imaging bacterial infections.https://www.mdpi.com/1999-4923/14/5/1008<sup>123</sup>I-BMIPPSPECTnuclear medicine imagingbacterial infectionbacterial imaging |
| spellingShingle | Yuka Muranaka Asuka Mizutani Masato Kobayashi Koya Nakamoto Miki Matsue Fumika Takagi Kenichi Okazaki Kodai Nishi Kana Yamazaki Ryuichi Nishii Naoto Shikano Shigefumi Okamoto Hideki Maki Keiichi Kawai <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging Pharmaceutics <sup>123</sup>I-BMIPP SPECT nuclear medicine imaging bacterial infection bacterial imaging |
| title | <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging |
| title_full | <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging |
| title_fullStr | <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging |
| title_full_unstemmed | <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging |
| title_short | <sup>123</sup>I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging |
| title_sort | sup 123 sup i bmipp a radiopharmaceutical for myocardial fatty acid metabolism scintigraphy could be utilized in bacterial infection imaging |
| topic | <sup>123</sup>I-BMIPP SPECT nuclear medicine imaging bacterial infection bacterial imaging |
| url | https://www.mdpi.com/1999-4923/14/5/1008 |
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