Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility
Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient t...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13396-8 |
| _version_ | 1819040489154805760 |
|---|---|
| author | Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup |
| author_facet | Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup |
| author_sort | Polina Kosillo |
| collection | DOAJ |
| description | Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility. |
| first_indexed | 2024-12-21T09:09:54Z |
| format | Article |
| id | doaj.art-8f206497b65e4d93a92d89d476e37c28 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:09:54Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8f206497b65e4d93a92d89d476e37c282022-12-21T19:09:15ZengNature PortfolioNature Communications2041-17232019-11-0110111910.1038/s41467-019-13396-8Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibilityPolina Kosillo0Natalie M. Doig1Kamran M. Ahmed2Alexander H.C.W. Agopyan-Miu3Corinna D. Wong4Lisa Conyers5Sarah Threlfell6Peter J. Magill7Helen S. Bateup8Department of Molecular and Cell Biology, University of California, BerkeleyMedical Research Council Brain Network Dynamics Unit, University of OxfordDepartment of Molecular and Cell Biology, University of California, BerkeleyDepartment of Molecular and Cell Biology, University of California, BerkeleyDepartment of Molecular and Cell Biology, University of California, BerkeleyMedical Research Council Brain Network Dynamics Unit, University of OxfordDepartment of Physiology, Anatomy and Genetics, University of OxfordMedical Research Council Brain Network Dynamics Unit, University of OxfordDepartment of Molecular and Cell Biology, University of California, BerkeleyTuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility.https://doi.org/10.1038/s41467-019-13396-8 |
| spellingShingle | Polina Kosillo Natalie M. Doig Kamran M. Ahmed Alexander H.C.W. Agopyan-Miu Corinna D. Wong Lisa Conyers Sarah Threlfell Peter J. Magill Helen S. Bateup Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility Nature Communications |
| title | Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility |
| title_full | Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility |
| title_fullStr | Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility |
| title_full_unstemmed | Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility |
| title_short | Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility |
| title_sort | tsc1 mtorc1 signaling controls striatal dopamine release and cognitive flexibility |
| url | https://doi.org/10.1038/s41467-019-13396-8 |
| work_keys_str_mv | AT polinakosillo tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT nataliemdoig tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT kamranmahmed tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT alexanderhcwagopyanmiu tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT corinnadwong tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT lisaconyers tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT sarahthrelfell tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT peterjmagill tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility AT helensbateup tsc1mtorc1signalingcontrolsstriataldopaminereleaseandcognitiveflexibility |