Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review
Fucoidans are sulfated heteropolysaccharides found in the cell walls of brown seaweeds (Phaeophyceae) and in some marine invertebrates. Generally, fucoidans are composed of significant amounts of L-fucose and sulfate groups, and lesser amounts of arabinose, galactose, glucose, glucuronic acid, manno...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/12/678 |
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| author | Kalu K. Asanka Sanjeewa Kalahe H. I. N. M. Herath Hye-Won Yang Cheol Soo Choi You-Jin Jeon |
| author_facet | Kalu K. Asanka Sanjeewa Kalahe H. I. N. M. Herath Hye-Won Yang Cheol Soo Choi You-Jin Jeon |
| author_sort | Kalu K. Asanka Sanjeewa |
| collection | DOAJ |
| description | Fucoidans are sulfated heteropolysaccharides found in the cell walls of brown seaweeds (Phaeophyceae) and in some marine invertebrates. Generally, fucoidans are composed of significant amounts of L-fucose and sulfate groups, and lesser amounts of arabinose, galactose, glucose, glucuronic acid, mannose, rhamnose, and xylose. In recent years, fucoidans isolated from brown seaweeds have gained considerable attention owing to their promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Inflammation is a complex immune response that protects the organs from infection and tissue injury. While controlled inflammatory responses are beneficial to the host, leading to the removal of immunostimulants from the host tissues and restoration of structural and physiological functions in the host tissues, chronic inflammatory responses are often associated with the pathogenesis of tumor development, arthritis, cardiovascular diseases, diabetes, obesity, and neurodegenerative diseases. In this review, the authors mainly discuss the studies since 2016 that have reported anti-inflammatory properties of fucoidans isolated from various brown seaweeds, and their potential as a novel functional material for the treatment of inflammatory diseases. |
| first_indexed | 2024-03-10T03:41:11Z |
| format | Article |
| id | doaj.art-8f20f0cd9004452aac574802c3821547 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T03:41:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8f20f0cd9004452aac574802c38215472023-11-23T09:18:08ZengMDPI AGMarine Drugs1660-33972021-11-01191267810.3390/md19120678Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A ReviewKalu K. Asanka Sanjeewa0Kalahe H. I. N. M. Herath1Hye-Won Yang2Cheol Soo Choi3You-Jin Jeon4Department of Biosystems Technology, Faculty of Technology, University of Sri Jayewardenepura, Pittpana, Homagoma 10200, Sri LankaDepartment of Biosystems Engineering, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila 60170, Sri LankaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaKorea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaFucoidans are sulfated heteropolysaccharides found in the cell walls of brown seaweeds (Phaeophyceae) and in some marine invertebrates. Generally, fucoidans are composed of significant amounts of L-fucose and sulfate groups, and lesser amounts of arabinose, galactose, glucose, glucuronic acid, mannose, rhamnose, and xylose. In recent years, fucoidans isolated from brown seaweeds have gained considerable attention owing to their promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Inflammation is a complex immune response that protects the organs from infection and tissue injury. While controlled inflammatory responses are beneficial to the host, leading to the removal of immunostimulants from the host tissues and restoration of structural and physiological functions in the host tissues, chronic inflammatory responses are often associated with the pathogenesis of tumor development, arthritis, cardiovascular diseases, diabetes, obesity, and neurodegenerative diseases. In this review, the authors mainly discuss the studies since 2016 that have reported anti-inflammatory properties of fucoidans isolated from various brown seaweeds, and their potential as a novel functional material for the treatment of inflammatory diseases.https://www.mdpi.com/1660-3397/19/12/678fucoidansbrown seaweedsinflammationMAPKschemokinescytokines |
| spellingShingle | Kalu K. Asanka Sanjeewa Kalahe H. I. N. M. Herath Hye-Won Yang Cheol Soo Choi You-Jin Jeon Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review Marine Drugs fucoidans brown seaweeds inflammation MAPKs chemokines cytokines |
| title | Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review |
| title_full | Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review |
| title_fullStr | Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review |
| title_full_unstemmed | Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review |
| title_short | Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review |
| title_sort | anti inflammatory mechanisms of fucoidans to treat inflammatory diseases a review |
| topic | fucoidans brown seaweeds inflammation MAPKs chemokines cytokines |
| url | https://www.mdpi.com/1660-3397/19/12/678 |
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