Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age
AP Momot,1 MG Nikolaeva,2 NN Yasafova,3 MS Zainulina,4 KA Momot,3 IA Taranenko31Altai Branch of FSBI, National Research Center for Hematology, Barnaul, Russia; 2Obstetrics and Gynecology Department with The Course in Supplementary Vocational Education at FSBI of Higher Education, Altai State Medical...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-08-01
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| Series: | Journal of Blood Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-and-laboratory-manifestations-of-the-prothrombin-gene-mutatio-peer-reviewed-article-JBM |
| _version_ | 1818825683040731136 |
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| author | Momot AP Nikolaeva MG Yasafova NN Zainulina MS Momot KA Taranenko IA |
| author_facet | Momot AP Nikolaeva MG Yasafova NN Zainulina MS Momot KA Taranenko IA |
| author_sort | Momot AP |
| collection | DOAJ |
| description | AP Momot,1 MG Nikolaeva,2 NN Yasafova,3 MS Zainulina,4 KA Momot,3 IA Taranenko31Altai Branch of FSBI, National Research Center for Hematology, Barnaul, Russia; 2Obstetrics and Gynecology Department with The Course in Supplementary Vocational Education at FSBI of Higher Education, Altai State Medical University, Barnaul, Russia; 3Altai Branch of FSBI, National Research Center for Hematology, Ministry of Healthcare of the Russian Federation, Barnaul, Russia; 4Saint Petersburg State-Financed Health Institution, “Maternity Hospital № 6 Named after Professor V.F. Snegirev”, Obstetrics, Gynecology and Reproductive Medicine Department, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaResearch objective: To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications.Materials and methods: A prospective clinical cohort study of 290 women of reproductive age was conducted. Two cohort groups were identified: the study group of 140 patients with prothrombin mutation G20210A genotype and the control group of 150 women with G20210G genotype.Results: The prothrombin G20210A mutation carriage is associated with the risk of thrombotic complications compared to the wild G20210G type (RR =17.1; p<0.0001) and is characterized by thrombosis localized both in the venous (66.7%) and arterial (33.3%) vascular pools. The threshold value of prothrombin activity (174.8%) for G20210A genotype was calculated, making it possible to conclusively predict the risk of thrombotic events with the accuracy of 90.4%.Conclusion: The phenotypic manifestation of the prothrombin G20210A mutation in the form of venous and arterial thromboses in women of reproductive age is associated with a super-threshold increase in prothrombin (factor II) activity, which makes it possible to stratify the patients into the group of high risk of thromboses.Keywords: prothrombin gene mutation, prothrombin mutation G20210A genotype, venous and arterial thromboses, prothrombin activity |
| first_indexed | 2024-12-19T00:15:39Z |
| format | Article |
| id | doaj.art-8f21d716bd394825b50160cf399c5170 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-19T00:15:39Z |
| publishDate | 2019-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-8f21d716bd394825b50160cf399c51702022-12-21T20:45:49ZengDove Medical PressJournal of Blood Medicine1179-27362019-08-01Volume 1025526347613Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive ageMomot APNikolaeva MGYasafova NNZainulina MSMomot KATaranenko IAAP Momot,1 MG Nikolaeva,2 NN Yasafova,3 MS Zainulina,4 KA Momot,3 IA Taranenko31Altai Branch of FSBI, National Research Center for Hematology, Barnaul, Russia; 2Obstetrics and Gynecology Department with The Course in Supplementary Vocational Education at FSBI of Higher Education, Altai State Medical University, Barnaul, Russia; 3Altai Branch of FSBI, National Research Center for Hematology, Ministry of Healthcare of the Russian Federation, Barnaul, Russia; 4Saint Petersburg State-Financed Health Institution, “Maternity Hospital № 6 Named after Professor V.F. Snegirev”, Obstetrics, Gynecology and Reproductive Medicine Department, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, RussiaResearch objective: To research the association of prothrombin (factor II) activity given the prothrombin G20210A mutation carriage with its clinical manifestations as thrombotic complications.Materials and methods: A prospective clinical cohort study of 290 women of reproductive age was conducted. Two cohort groups were identified: the study group of 140 patients with prothrombin mutation G20210A genotype and the control group of 150 women with G20210G genotype.Results: The prothrombin G20210A mutation carriage is associated with the risk of thrombotic complications compared to the wild G20210G type (RR =17.1; p<0.0001) and is characterized by thrombosis localized both in the venous (66.7%) and arterial (33.3%) vascular pools. The threshold value of prothrombin activity (174.8%) for G20210A genotype was calculated, making it possible to conclusively predict the risk of thrombotic events with the accuracy of 90.4%.Conclusion: The phenotypic manifestation of the prothrombin G20210A mutation in the form of venous and arterial thromboses in women of reproductive age is associated with a super-threshold increase in prothrombin (factor II) activity, which makes it possible to stratify the patients into the group of high risk of thromboses.Keywords: prothrombin gene mutation, prothrombin mutation G20210A genotype, venous and arterial thromboses, prothrombin activityhttps://www.dovepress.com/clinical-and-laboratory-manifestations-of-the-prothrombin-gene-mutatio-peer-reviewed-article-JBMprothrombin gene mutationprothrombin mutation G20210A genotypevenous and arterial thrombosesprothrombin activity. |
| spellingShingle | Momot AP Nikolaeva MG Yasafova NN Zainulina MS Momot KA Taranenko IA Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age Journal of Blood Medicine prothrombin gene mutation prothrombin mutation G20210A genotype venous and arterial thromboses prothrombin activity. |
| title | Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| title_full | Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| title_fullStr | Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| title_full_unstemmed | Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| title_short | Clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| title_sort | clinical and laboratory manifestations of the prothrombin gene mutation in women of reproductive age |
| topic | prothrombin gene mutation prothrombin mutation G20210A genotype venous and arterial thromboses prothrombin activity. |
| url | https://www.dovepress.com/clinical-and-laboratory-manifestations-of-the-prothrombin-gene-mutatio-peer-reviewed-article-JBM |
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