Nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma

Nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for about 8% of childhood cancers. Despite aggressive treatment, patients suffering from high-risk NB have very poor 5-year overall survival rate, due to relapsed and/or treatment-resistant tumors. A further incre...

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Bibliographic Details
Main Authors: Fabio ePastorino, Chiara eBrignole, Monica eLoi, Daniela eDi Paolo, Annarita eDi Fiore, Patrizia ePerri, Gabriella ePagnan, Mirco ePonzoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Oncology
Subjects:
Neuroblastoma
tumor vasculature
Drug delivery
targeted therapies
nanocarriers
tumor uptake
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00190/full

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