Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine
In this study, the electrochemical determination of Ivabradine hydrochloride (IH) was studied in detail using a glassy carbon electrode (GCE) modified with mesoporous carbon solution (MCS) and carboxylated group linked single-walled carbon nanotube (SWCNT-COOH). The developed nanosensor showed a sig...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Analytica |
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| Online Access: | https://www.mdpi.com/2673-4532/2/4/17 |
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| author | Merve Yence Leyla Karadurmus Goksu Ozcelikay Nurgul K. Bakirhan Sibel A. Ozkan |
| author_facet | Merve Yence Leyla Karadurmus Goksu Ozcelikay Nurgul K. Bakirhan Sibel A. Ozkan |
| author_sort | Merve Yence |
| collection | DOAJ |
| description | In this study, the electrochemical determination of Ivabradine hydrochloride (IH) was studied in detail using a glassy carbon electrode (GCE) modified with mesoporous carbon solution (MCS) and carboxylated group linked single-walled carbon nanotube (SWCNT-COOH). The developed nanosensor showed a significant effect by remarkably increasing the IH signal compared with the bare GCE. Cyclic (CV) and differential pulse voltammetric (DPV) methods were applied to perform electrochemical analysis of IH in pH 3.0 BRB solutions. The calibration plot for IH with a detection limit of 1.47 × 10<sup>−7</sup> M was obtained using the DPV technique in the range of 1–10 µM under optimum experimental conditions. The proposed method has been validated and applied for the detection of the IH tablet. The produced nanosensor was also performed for the determination of IH in serum and urine. Excellent recoveries of 98.4%, 98.0%, and 100.2% were achieved for tablet, serum, and urine analysis, respectively. |
| first_indexed | 2024-03-10T04:40:40Z |
| format | Article |
| id | doaj.art-8f2788ae09e9417da78a0eed768306eb |
| institution | Directory Open Access Journal |
| issn | 2673-4532 |
| language | English |
| last_indexed | 2024-03-10T04:40:40Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Analytica |
| spelling | doaj.art-8f2788ae09e9417da78a0eed768306eb2023-11-23T03:25:17ZengMDPI AGAnalytica2673-45322021-12-012419520510.3390/analytica2040017Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of IvabradineMerve Yence0Leyla Karadurmus1Goksu Ozcelikay2Nurgul K. Bakirhan3Sibel A. Ozkan4Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyDepartment of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06010, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara 06560, TurkeyIn this study, the electrochemical determination of Ivabradine hydrochloride (IH) was studied in detail using a glassy carbon electrode (GCE) modified with mesoporous carbon solution (MCS) and carboxylated group linked single-walled carbon nanotube (SWCNT-COOH). The developed nanosensor showed a significant effect by remarkably increasing the IH signal compared with the bare GCE. Cyclic (CV) and differential pulse voltammetric (DPV) methods were applied to perform electrochemical analysis of IH in pH 3.0 BRB solutions. The calibration plot for IH with a detection limit of 1.47 × 10<sup>−7</sup> M was obtained using the DPV technique in the range of 1–10 µM under optimum experimental conditions. The proposed method has been validated and applied for the detection of the IH tablet. The produced nanosensor was also performed for the determination of IH in serum and urine. Excellent recoveries of 98.4%, 98.0%, and 100.2% were achieved for tablet, serum, and urine analysis, respectively.https://www.mdpi.com/2673-4532/2/4/17ivabradine hydrochloridenanosensorglassy carbon electrodemesoporous carbon solutionCOOH functionalized SWCNT |
| spellingShingle | Merve Yence Leyla Karadurmus Goksu Ozcelikay Nurgul K. Bakirhan Sibel A. Ozkan Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine Analytica ivabradine hydrochloride nanosensor glassy carbon electrode mesoporous carbon solution COOH functionalized SWCNT |
| title | Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine |
| title_full | Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine |
| title_fullStr | Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine |
| title_full_unstemmed | Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine |
| title_short | Achievements of Mesoporous Carbon Solution and Single-Walled Carbon Nanotube Composite on the Sensitive Electrochemical Assay of Ivabradine |
| title_sort | achievements of mesoporous carbon solution and single walled carbon nanotube composite on the sensitive electrochemical assay of ivabradine |
| topic | ivabradine hydrochloride nanosensor glassy carbon electrode mesoporous carbon solution COOH functionalized SWCNT |
| url | https://www.mdpi.com/2673-4532/2/4/17 |
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