Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review
Alzheimer's Disease (AD) is a multifactorial and complex neurodegenerative disorder. Some modifiable risk factors have been associated with an increased risk of appearance of the disease and/or cognitive decline. Preventive clinical trials aiming at reducing one or combined risk factors have be...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1014559/full |
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| author | Lisa Perus Lisa Perus Lisa Perus Lisa Perus Germain U. Busto Germain U. Busto Jean-François Mangin Jean-François Mangin Emmanuelle Le Bars Audrey Gabelle Audrey Gabelle |
| author_facet | Lisa Perus Lisa Perus Lisa Perus Lisa Perus Germain U. Busto Germain U. Busto Jean-François Mangin Jean-François Mangin Emmanuelle Le Bars Audrey Gabelle Audrey Gabelle |
| author_sort | Lisa Perus |
| collection | DOAJ |
| description | Alzheimer's Disease (AD) is a multifactorial and complex neurodegenerative disorder. Some modifiable risk factors have been associated with an increased risk of appearance of the disease and/or cognitive decline. Preventive clinical trials aiming at reducing one or combined risk factors have been implemented and their potential effects assessed on cognitive trajectories and on AD biomarkers. However, the effect of interventions on surrogate markers, in particular imaging biomarkers, remains poorly understood. We conducted a review of the literature and analyzed 43 interventional studies that included physical exercise, nutrition, cognitive training or multidomain interventions, and assessed various brain imaging biomarkers, to determine the effects of preventive interventions on imaging biomarkers for subjects at-risk to develop AD. Deciphering the global and regional brain effect of each and combined interventions will help to better understand the interplay relationship between multimodal interventions, cognition, surrogate brain markers, and to better design primary and secondary outcomes for future preventive clinical trials. Those studies were pondered using generally-admitted quality criteria to reveal that interventions may affect the brain of patients with cognitive impairment rather than those without cognitive impairment thus indicating that particular care should be taken when selecting individuals for interventions. Additionally, a majority of the studies concurred on the effect of the interventions and particularly onto the frontal brain areas. |
| first_indexed | 2024-04-11T06:41:37Z |
| format | Article |
| id | doaj.art-8f28bd8e1c0440fe96f182d4b9018658 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T06:41:37Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8f28bd8e1c0440fe96f182d4b90186582022-12-22T04:39:30ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10145591014559Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic reviewLisa Perus0Lisa Perus1Lisa Perus2Lisa Perus3Germain U. Busto4Germain U. Busto5Jean-François Mangin6Jean-François Mangin7Emmanuelle Le Bars8Audrey Gabelle9Audrey Gabelle10INM, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, FranceDepartment of Neurology, Memory Resources and Research Center, Gui de Chauliac Hospital, Montpellier, FranceInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, FranceCATI, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Ile de France, FranceINM, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, FranceDepartment of Neurology, Memory Resources and Research Center, Gui de Chauliac Hospital, Montpellier, FranceCATI, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM, APHP, Ile de France, FranceUniversité Paris-Saclay, CEA, CNRS, Neurospin, UMR9027 Baobab, Gif-sur-Yvette, FranceInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, FranceINM, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, FranceDepartment of Neurology, Memory Resources and Research Center, Gui de Chauliac Hospital, Montpellier, FranceAlzheimer's Disease (AD) is a multifactorial and complex neurodegenerative disorder. Some modifiable risk factors have been associated with an increased risk of appearance of the disease and/or cognitive decline. Preventive clinical trials aiming at reducing one or combined risk factors have been implemented and their potential effects assessed on cognitive trajectories and on AD biomarkers. However, the effect of interventions on surrogate markers, in particular imaging biomarkers, remains poorly understood. We conducted a review of the literature and analyzed 43 interventional studies that included physical exercise, nutrition, cognitive training or multidomain interventions, and assessed various brain imaging biomarkers, to determine the effects of preventive interventions on imaging biomarkers for subjects at-risk to develop AD. Deciphering the global and regional brain effect of each and combined interventions will help to better understand the interplay relationship between multimodal interventions, cognition, surrogate brain markers, and to better design primary and secondary outcomes for future preventive clinical trials. Those studies were pondered using generally-admitted quality criteria to reveal that interventions may affect the brain of patients with cognitive impairment rather than those without cognitive impairment thus indicating that particular care should be taken when selecting individuals for interventions. Additionally, a majority of the studies concurred on the effect of the interventions and particularly onto the frontal brain areas.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1014559/fullnutritioncognitive trainingphysical exercisemultidomain interventionbrain imagingAlzheimer's disease |
| spellingShingle | Lisa Perus Lisa Perus Lisa Perus Lisa Perus Germain U. Busto Germain U. Busto Jean-François Mangin Jean-François Mangin Emmanuelle Le Bars Audrey Gabelle Audrey Gabelle Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review Frontiers in Aging Neuroscience nutrition cognitive training physical exercise multidomain intervention brain imaging Alzheimer's disease |
| title | Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review |
| title_full | Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review |
| title_fullStr | Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review |
| title_full_unstemmed | Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review |
| title_short | Effects of preventive interventions on neuroimaging biomarkers in subjects at-risk to develop Alzheimer's disease: A systematic review |
| title_sort | effects of preventive interventions on neuroimaging biomarkers in subjects at risk to develop alzheimer s disease a systematic review |
| topic | nutrition cognitive training physical exercise multidomain intervention brain imaging Alzheimer's disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1014559/full |
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