Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon
Diarrhea is a condition that particularly affects children under five the age of years old in developing countries. The aim of this study was to evaluate the efficacy of medicinal extracts plants used in treatment and to characterize their inhibitory capacity in the growth of bacteria isolates in ch...
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MDPI AG
2023-10-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/20/3629 |
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| author | Jean Fabrice Yala Rolande Mabika Mabika Davy U. Ikabanga Franck Mounioko Prince Rodrigue Mokouapamba Alexis Nicaise Lepengue Alain Souza |
| author_facet | Jean Fabrice Yala Rolande Mabika Mabika Davy U. Ikabanga Franck Mounioko Prince Rodrigue Mokouapamba Alexis Nicaise Lepengue Alain Souza |
| author_sort | Jean Fabrice Yala |
| collection | DOAJ |
| description | Diarrhea is a condition that particularly affects children under five the age of years old in developing countries. The aim of this study was to evaluate the efficacy of medicinal extracts plants used in treatment and to characterize their inhibitory capacity in the growth of bacteria isolates in childhood diarrhea in the southeast region of Gabon. An ethnobotanical survey on the plants used in the treatment of diarrhea in southeastern Gabon was carried out and a phytochemical screening of the collected plants was performed. The antimicrobial activity of aqueous extracts was evaluated; 33 plant species were identified, representing 28 genera and 19 families. Bark (39.5%) was the most commonly used plant part, followed by powder formulations (28.9%). The preferred method of preparation and chewing (44.7%), together with drinking (36.8%), were the most prevalent modes of administration. Phytochemical screening showed a plethora of secondary metabolites (terpenoids, alkaloids and phenolic compounds), and a marked level of anti-diarrheal activity was found with <i>Sida acuta</i> and <i>Santiria. ebo</i> against <i>Shigella</i> spp. (16.22 ± 0.7 mm and 14.05 ± 1.4 mm) and <i>Yersinia pestis</i> (16.35 ± 0.5 mm and 15.51 ± 0.5 mm). The high diversity of secondary plant metabolites and their inhibitory ability against enteric pathogens would justify their use at the local level to treat diarrheal infections. |
| first_indexed | 2024-03-10T20:56:46Z |
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| id | doaj.art-8f29e8030dd249cea1d3bcefc621539a |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T20:56:46Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Plants |
| spelling | doaj.art-8f29e8030dd249cea1d3bcefc621539a2023-11-19T17:49:44ZengMDPI AGPlants2223-77472023-10-011220362910.3390/plants12203629Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern GabonJean Fabrice Yala0Rolande Mabika Mabika1Davy U. Ikabanga2Franck Mounioko3Prince Rodrigue Mokouapamba4Alexis Nicaise Lepengue5Alain Souza6Bacteriology Laboratory, Unity for Research Medical Analysis of the Interdisciplinary, Centre of Medical Research of Franceville (CIRMF), Franceville BP 769, GabonBacteriology Laboratory, Unity for Research Medical Analysis of the Interdisciplinary, Centre of Medical Research of Franceville (CIRMF), Franceville BP 769, GabonLaboratory of Plant Physiology, Phytopathology and Plant Breeding, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, GabonLaboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, GabonLaboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, GabonLaboratory of Plant Physiology, Phytopathology and Plant Breeding, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, GabonLaboratory of Molecular and Cellular Biology, Bacteriology-Immunology Team, Agrobiology Research Unit, University of Science and Technology of Masuku (USTM), Franceville BP 067, GabonDiarrhea is a condition that particularly affects children under five the age of years old in developing countries. The aim of this study was to evaluate the efficacy of medicinal extracts plants used in treatment and to characterize their inhibitory capacity in the growth of bacteria isolates in childhood diarrhea in the southeast region of Gabon. An ethnobotanical survey on the plants used in the treatment of diarrhea in southeastern Gabon was carried out and a phytochemical screening of the collected plants was performed. The antimicrobial activity of aqueous extracts was evaluated; 33 plant species were identified, representing 28 genera and 19 families. Bark (39.5%) was the most commonly used plant part, followed by powder formulations (28.9%). The preferred method of preparation and chewing (44.7%), together with drinking (36.8%), were the most prevalent modes of administration. Phytochemical screening showed a plethora of secondary metabolites (terpenoids, alkaloids and phenolic compounds), and a marked level of anti-diarrheal activity was found with <i>Sida acuta</i> and <i>Santiria. ebo</i> against <i>Shigella</i> spp. (16.22 ± 0.7 mm and 14.05 ± 1.4 mm) and <i>Yersinia pestis</i> (16.35 ± 0.5 mm and 15.51 ± 0.5 mm). The high diversity of secondary plant metabolites and their inhibitory ability against enteric pathogens would justify their use at the local level to treat diarrheal infections.https://www.mdpi.com/2223-7747/12/20/3629ethnopharmacological efficacyantimicrobial activityphytochemical screeninganti-diarrheal plants |
| spellingShingle | Jean Fabrice Yala Rolande Mabika Mabika Davy U. Ikabanga Franck Mounioko Prince Rodrigue Mokouapamba Alexis Nicaise Lepengue Alain Souza Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon Plants ethnopharmacological efficacy antimicrobial activity phytochemical screening anti-diarrheal plants |
| title | Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon |
| title_full | Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon |
| title_fullStr | Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon |
| title_full_unstemmed | Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon |
| title_short | Ethnopharmacological Survey, Phytochemical Screening and Antimicrobial Activities of Medicinal Plants Used in the Treatment of Diarrhea in Southeastern Gabon |
| title_sort | ethnopharmacological survey phytochemical screening and antimicrobial activities of medicinal plants used in the treatment of diarrhea in southeastern gabon |
| topic | ethnopharmacological efficacy antimicrobial activity phytochemical screening anti-diarrheal plants |
| url | https://www.mdpi.com/2223-7747/12/20/3629 |
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