Fast and slow feedforward inhibitory circuits for cortical odor processing
Feedforward inhibitory circuits are key contributors to the complex interplay between excitation and inhibition in the brain. Little is known about the function of feedforward inhibition in the primary olfactory (piriform) cortex. Using in vivo two-photon-targeted patch clamping and calcium imaging...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/73406 |
| _version_ | 1818026584287739904 |
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| author | Norimitsu Suzuki Malinda LS Tantirigama K Phyu Aung Helena HY Huang John M Bekkers |
| author_facet | Norimitsu Suzuki Malinda LS Tantirigama K Phyu Aung Helena HY Huang John M Bekkers |
| author_sort | Norimitsu Suzuki |
| collection | DOAJ |
| description | Feedforward inhibitory circuits are key contributors to the complex interplay between excitation and inhibition in the brain. Little is known about the function of feedforward inhibition in the primary olfactory (piriform) cortex. Using in vivo two-photon-targeted patch clamping and calcium imaging in mice, we find that odors evoke strong excitation in two classes of interneurons – neurogliaform (NG) cells and horizontal (HZ) cells – that provide feedforward inhibition in layer 1 of the piriform cortex. NG cells fire much earlier than HZ cells following odor onset, a difference that can be attributed to the faster odor-driven excitatory synaptic drive that NG cells receive from the olfactory bulb. As a result, NG cells strongly but transiently inhibit odor-evoked excitation in layer 2 principal cells, whereas HZ cells provide more diffuse and prolonged feedforward inhibition. Our findings reveal unexpected complexity in the operation of inhibition in the piriform cortex. |
| first_indexed | 2024-12-10T04:34:19Z |
| format | Article |
| id | doaj.art-8f2cb2613181442faa274c50a1f14d1e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:34:19Z |
| publishDate | 2022-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8f2cb2613181442faa274c50a1f14d1e2022-12-22T02:02:04ZengeLife Sciences Publications LtdeLife2050-084X2022-03-011110.7554/eLife.73406Fast and slow feedforward inhibitory circuits for cortical odor processingNorimitsu Suzuki0https://orcid.org/0000-0002-9338-9099Malinda LS Tantirigama1https://orcid.org/0000-0003-0791-9389K Phyu Aung2https://orcid.org/0000-0003-3744-5321Helena HY Huang3https://orcid.org/0000-0002-1283-8586John M Bekkers4https://orcid.org/0000-0001-8619-5512Eccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, AustraliaEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, Australia; Neurocure Center for Excellence, Charité Universitätsmedizin Berlin and Humboldt Universität, Berlin, GermanyEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, AustraliaEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, AustraliaEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, AustraliaFeedforward inhibitory circuits are key contributors to the complex interplay between excitation and inhibition in the brain. Little is known about the function of feedforward inhibition in the primary olfactory (piriform) cortex. Using in vivo two-photon-targeted patch clamping and calcium imaging in mice, we find that odors evoke strong excitation in two classes of interneurons – neurogliaform (NG) cells and horizontal (HZ) cells – that provide feedforward inhibition in layer 1 of the piriform cortex. NG cells fire much earlier than HZ cells following odor onset, a difference that can be attributed to the faster odor-driven excitatory synaptic drive that NG cells receive from the olfactory bulb. As a result, NG cells strongly but transiently inhibit odor-evoked excitation in layer 2 principal cells, whereas HZ cells provide more diffuse and prolonged feedforward inhibition. Our findings reveal unexpected complexity in the operation of inhibition in the piriform cortex.https://elifesciences.org/articles/73406piriform cortexinhibitionolfaction |
| spellingShingle | Norimitsu Suzuki Malinda LS Tantirigama K Phyu Aung Helena HY Huang John M Bekkers Fast and slow feedforward inhibitory circuits for cortical odor processing eLife piriform cortex inhibition olfaction |
| title | Fast and slow feedforward inhibitory circuits for cortical odor processing |
| title_full | Fast and slow feedforward inhibitory circuits for cortical odor processing |
| title_fullStr | Fast and slow feedforward inhibitory circuits for cortical odor processing |
| title_full_unstemmed | Fast and slow feedforward inhibitory circuits for cortical odor processing |
| title_short | Fast and slow feedforward inhibitory circuits for cortical odor processing |
| title_sort | fast and slow feedforward inhibitory circuits for cortical odor processing |
| topic | piriform cortex inhibition olfaction |
| url | https://elifesciences.org/articles/73406 |
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