Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status
Abstract Aims/Introduction We investigated the association of polyneuropathy (PN) with all‐cause and cardiovascular (CV) mortality and with cardiovascular disease (CVD) events stratified by diabetes status. Materials and Methods This prospective cohort study used the UK Biobank. Polyneuropathy was d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.14063 |
| _version_ | 1827790926993424384 |
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| author | Kyuho Kim Su‐Nam Lee Yu‐Bae Ahn Seung‐Hyun Ko Jae‐Seung Yun |
| author_facet | Kyuho Kim Su‐Nam Lee Yu‐Bae Ahn Seung‐Hyun Ko Jae‐Seung Yun |
| author_sort | Kyuho Kim |
| collection | DOAJ |
| description | Abstract Aims/Introduction We investigated the association of polyneuropathy (PN) with all‐cause and cardiovascular (CV) mortality and with cardiovascular disease (CVD) events stratified by diabetes status. Materials and Methods This prospective cohort study used the UK Biobank. Polyneuropathy was defined based on nurse‐led interviews or ICD codes for polyneuropathy. Cox proportional hazards models were used to investigate the association of polyneuropathy with clinical outcomes. Results A total of 459,127 participants were included in the analysis. Polyneuropathy was significantly associated with all‐cause and cardiovascular mortality, and with CVD events even after adjusting for CVD risk factors across all diabetes statuses. Metabolic parameters HbA1c, waist circumference, BMI and the inflammatory parameter C‐reactive protein showed significant mediation effects for the association between polyneuropathy and CVD. Adherence to a favorable lifestyle was associated with a lower risk of all‐cause and cardiovascular mortality regardless of polyneuropathy status. Conclusions Polyneuropathy was associated with all‐cause and cardiovascular mortality, and with CVD events in subjects with diabetes or prediabetes, even those having normal glucose tolerance. This study suggests the importance of polyneuropathy as a risk factor for death and highlights the necessity of early diagnosis and lifestyle intervention for those with type 2 diabetes and polyneuropathy. |
| first_indexed | 2024-03-11T17:39:56Z |
| format | Article |
| id | doaj.art-8f2d02293adc48dcaec95d31f809f07c |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-03-11T17:39:56Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-8f2d02293adc48dcaec95d31f809f07c2023-10-18T13:00:35ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-11-0114111279128810.1111/jdi.14063Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes statusKyuho Kim0Su‐Nam Lee1Yu‐Bae Ahn2Seung‐Hyun Ko3Jae‐Seung Yun4Department of Internal Medicine, College of Medicine The Catholic University of Korea Seoul KoreaDivision of Cardiology, Department of Internal Medicine St Vincent's Hospital, The Catholic University of Korea Suwon KoreaDepartment of Internal Medicine, College of Medicine The Catholic University of Korea Seoul KoreaDepartment of Internal Medicine, College of Medicine The Catholic University of Korea Seoul KoreaDepartment of Internal Medicine, College of Medicine The Catholic University of Korea Seoul KoreaAbstract Aims/Introduction We investigated the association of polyneuropathy (PN) with all‐cause and cardiovascular (CV) mortality and with cardiovascular disease (CVD) events stratified by diabetes status. Materials and Methods This prospective cohort study used the UK Biobank. Polyneuropathy was defined based on nurse‐led interviews or ICD codes for polyneuropathy. Cox proportional hazards models were used to investigate the association of polyneuropathy with clinical outcomes. Results A total of 459,127 participants were included in the analysis. Polyneuropathy was significantly associated with all‐cause and cardiovascular mortality, and with CVD events even after adjusting for CVD risk factors across all diabetes statuses. Metabolic parameters HbA1c, waist circumference, BMI and the inflammatory parameter C‐reactive protein showed significant mediation effects for the association between polyneuropathy and CVD. Adherence to a favorable lifestyle was associated with a lower risk of all‐cause and cardiovascular mortality regardless of polyneuropathy status. Conclusions Polyneuropathy was associated with all‐cause and cardiovascular mortality, and with CVD events in subjects with diabetes or prediabetes, even those having normal glucose tolerance. This study suggests the importance of polyneuropathy as a risk factor for death and highlights the necessity of early diagnosis and lifestyle intervention for those with type 2 diabetes and polyneuropathy.https://doi.org/10.1111/jdi.14063Cardiovascular diseasesDiabetes mellitusPolyneuropathies |
| spellingShingle | Kyuho Kim Su‐Nam Lee Yu‐Bae Ahn Seung‐Hyun Ko Jae‐Seung Yun Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status Journal of Diabetes Investigation Cardiovascular diseases Diabetes mellitus Polyneuropathies |
| title | Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status |
| title_full | Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status |
| title_fullStr | Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status |
| title_full_unstemmed | Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status |
| title_short | Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status |
| title_sort | associations of polyneuropathy with risk of all cause and cardiovascular mortality cardiovascular disease events stratified by diabetes status |
| topic | Cardiovascular diseases Diabetes mellitus Polyneuropathies |
| url | https://doi.org/10.1111/jdi.14063 |
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