Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis
Objective: As an indicator of variability in circulating erythrocyte size, red cell distribution width (RDW) is linked to chronic inflammation. The association of rheumatic heart valve stenosis and inflammation is also well-known. This study aimed to assess the relationship between RDW and presence...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2015-04-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-60533 |
| _version_ | 1797906965894004736 |
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| author | Mehmet Kadri Akboga Adnan Abacı Uğur Canpolat Cağrı Yayla Asife Sahinarslan Kadri Açıkgöz Serkan Çay Serkan Topaloğlu Dursun Aras Sinan Aydoğdu |
| author_facet | Mehmet Kadri Akboga Adnan Abacı Uğur Canpolat Cağrı Yayla Asife Sahinarslan Kadri Açıkgöz Serkan Çay Serkan Topaloğlu Dursun Aras Sinan Aydoğdu |
| author_sort | Mehmet Kadri Akboga |
| collection | DOAJ |
| description | Objective: As an indicator of variability in circulating erythrocyte size, red cell distribution width (RDW) is linked to chronic inflammation. The association of rheumatic heart valve stenosis and inflammation is also well-known. This study aimed to assess the relationship between RDW and presence and severity of rheumatic mitral valve stenosis (RMVS).
Methods: A total of 417 consecutive patients with RMVS, and 81 age- and -gender matched healthy control subjects were included in the study between February 2009 and April 2014. Transthoracic echocardiography and demographic characteristics were recorded for all participants.
Results: Baseline characteristics were similar in the two groups. However, median RDW was significantly higher in patients with RMVS compared to control group (14.4% [11.3- 19.6] vs. 13.6% [11.6-18.1], p<0.001). Additionally, both median C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were also higher in the RMVS group; (6.1 [0.4-24.2] vs. 3.6 [0.3-15.3] mg/dl, p=0.001 for CRP, and 2.8 [0.4-10.6] vs. 2.1 [0.7-5.7], p<0.001 for NLR respectively). In regression analysis, RDW (OR: 1.504, p=0.005), CRP (OR: 1.139, p=0.008), NLR (OR: 1.528, p=0.018) and left atrial diameter (OR: 1.218, p<0.001) were found as independent predictors of the presence of RMVS. Furthermore, there was a significant positive correlation between CRP (r=0.140, p=0.007) and NLR levels (r=0.276, p<0.001) with RDW levels. Furthermore, we determined that RDW levels increased in parallel with severity of mitral stenosis (mild, moderate and severe) [13.7% (12.9-14.8), 14.4% (13.4-15.4), 14.8% (13.6-16.3), p<0.001, respectively].
Conclusion: The study demonstrated significantly higher RDW in patients with RMVS. Furthermore, RDW independently predicted the presence of RMVS. RDW is an easily available marker, and because of its correlation with common inflammatory indicators may also be a sign of chronic inflammatory continuum in patients with RMVS. |
| first_indexed | 2024-04-10T10:28:59Z |
| format | Article |
| id | doaj.art-8f2dc8558d7a4c3181020d3fd2f97ca5 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T10:28:59Z |
| publishDate | 2015-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-8f2dc8558d7a4c3181020d3fd2f97ca52023-02-15T16:21:15ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692015-04-0143322723310.5543/tkda.2015.60533TKDA-60533Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosisMehmet Kadri Akboga0Adnan Abacı1Uğur Canpolat2Cağrı Yayla3Asife Sahinarslan4Kadri Açıkgöz5Serkan Çay6Serkan Topaloğlu7Dursun Aras8Sinan Aydoğdu9Turkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyGazi University Medical Faculty, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyGazi University Medical Faculty, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, TurkeyObjective: As an indicator of variability in circulating erythrocyte size, red cell distribution width (RDW) is linked to chronic inflammation. The association of rheumatic heart valve stenosis and inflammation is also well-known. This study aimed to assess the relationship between RDW and presence and severity of rheumatic mitral valve stenosis (RMVS). Methods: A total of 417 consecutive patients with RMVS, and 81 age- and -gender matched healthy control subjects were included in the study between February 2009 and April 2014. Transthoracic echocardiography and demographic characteristics were recorded for all participants. Results: Baseline characteristics were similar in the two groups. However, median RDW was significantly higher in patients with RMVS compared to control group (14.4% [11.3- 19.6] vs. 13.6% [11.6-18.1], p<0.001). Additionally, both median C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were also higher in the RMVS group; (6.1 [0.4-24.2] vs. 3.6 [0.3-15.3] mg/dl, p=0.001 for CRP, and 2.8 [0.4-10.6] vs. 2.1 [0.7-5.7], p<0.001 for NLR respectively). In regression analysis, RDW (OR: 1.504, p=0.005), CRP (OR: 1.139, p=0.008), NLR (OR: 1.528, p=0.018) and left atrial diameter (OR: 1.218, p<0.001) were found as independent predictors of the presence of RMVS. Furthermore, there was a significant positive correlation between CRP (r=0.140, p=0.007) and NLR levels (r=0.276, p<0.001) with RDW levels. Furthermore, we determined that RDW levels increased in parallel with severity of mitral stenosis (mild, moderate and severe) [13.7% (12.9-14.8), 14.4% (13.4-15.4), 14.8% (13.6-16.3), p<0.001, respectively]. Conclusion: The study demonstrated significantly higher RDW in patients with RMVS. Furthermore, RDW independently predicted the presence of RMVS. RDW is an easily available marker, and because of its correlation with common inflammatory indicators may also be a sign of chronic inflammatory continuum in patients with RMVS.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-60533inflammationred cell distribution width; mitral valve stenosis; rheumatic mitral stenosis. |
| spellingShingle | Mehmet Kadri Akboga Adnan Abacı Uğur Canpolat Cağrı Yayla Asife Sahinarslan Kadri Açıkgöz Serkan Çay Serkan Topaloğlu Dursun Aras Sinan Aydoğdu Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis Türk Kardiyoloji Derneği Arşivi inflammation red cell distribution width; mitral valve stenosis; rheumatic mitral stenosis. |
| title | Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| title_full | Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| title_fullStr | Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| title_full_unstemmed | Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| title_short | Association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| title_sort | association of red blood cell distribution width with presence and severity of rheumatic mitral valve stenosis |
| topic | inflammation red cell distribution width; mitral valve stenosis; rheumatic mitral stenosis. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-60533 |
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