Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease
Three months of exercise training (ET) decreases soluble Aβ<sub>40</sub> and Aβ<sub>42</sub> levels in an intensity dependent manner early in life in Tg2576 mice (Moore et al., 2016). Here, we examined the effects of 12 months of low- and high- intensity exe...
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MDPI AG
2020-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/2/88 |
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| author | Riya Thomas Scott D. Zimmerman Kayla M. Yuede John R. Cirrito Leon M. Tai Benjamin F. Timson Carla M. Yuede |
| author_facet | Riya Thomas Scott D. Zimmerman Kayla M. Yuede John R. Cirrito Leon M. Tai Benjamin F. Timson Carla M. Yuede |
| author_sort | Riya Thomas |
| collection | DOAJ |
| description | Three months of exercise training (ET) decreases soluble Aβ<sub>40</sub> and Aβ<sub>42</sub> levels in an intensity dependent manner early in life in Tg2576 mice (Moore et al., 2016). Here, we examined the effects of 12 months of low- and high- intensity exercise training on cognitive function and amyloid plaque load in the cortex and hippocampus of 15-month-old Tg2576 mice. Low- (LOW) and high- (HI) intensity ET animals ran at speeds of 15 m/min on a level treadmill and 32 m/min at a 10% grade, respectively, for 60 min/day, five days/week, from 3 to 15 months of age. Sedentary mice (SED) were placed on a level, non-moving, treadmill for the same duration. ET mice demonstrated a significantly lower amyloid plaque load in the cortex and hippocampus that was intensity dependent. Improvement in cognitive function, assessed by Morris Water Maze and Novel Object Recognition tests, was greater in the HI group compared to the LOW and SED groups. LOW mice performed better in the initial latency to the platform location during the probe trial of the Morris Water Maze (MWM) test than SED, but not in any other aspect of MWM or the Novel Object Recognition test. The results of this study indicate that exercise training decreases amyloid plaque load in an intensity dependent manner and that high-intensity exercise training improves cognitive function relative to SED mice, but the intensity of the LOW group was below the threshold to demonstrate robust improvement in cognitive function in Tg2576 mice. |
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| language | English |
| last_indexed | 2024-12-11T13:31:19Z |
| publishDate | 2020-02-01 |
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| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-8f2f3b1cfdb2442db920a1b87177eaa82022-12-22T01:05:16ZengMDPI AGBrain Sciences2076-34252020-02-011028810.3390/brainsci10020088brainsci10020088Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s DiseaseRiya Thomas0Scott D. Zimmerman1Kayla M. Yuede2John R. Cirrito3Leon M. Tai4Benjamin F. Timson5Carla M. Yuede6Department of Biomedical Sciences, Missouri State University, Springfield, MO 65897, USADepartment of Biomedical Sciences, Missouri State University, Springfield, MO 65897, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60607, USADepartment of Biomedical Sciences, Missouri State University, Springfield, MO 65897, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USAThree months of exercise training (ET) decreases soluble Aβ<sub>40</sub> and Aβ<sub>42</sub> levels in an intensity dependent manner early in life in Tg2576 mice (Moore et al., 2016). Here, we examined the effects of 12 months of low- and high- intensity exercise training on cognitive function and amyloid plaque load in the cortex and hippocampus of 15-month-old Tg2576 mice. Low- (LOW) and high- (HI) intensity ET animals ran at speeds of 15 m/min on a level treadmill and 32 m/min at a 10% grade, respectively, for 60 min/day, five days/week, from 3 to 15 months of age. Sedentary mice (SED) were placed on a level, non-moving, treadmill for the same duration. ET mice demonstrated a significantly lower amyloid plaque load in the cortex and hippocampus that was intensity dependent. Improvement in cognitive function, assessed by Morris Water Maze and Novel Object Recognition tests, was greater in the HI group compared to the LOW and SED groups. LOW mice performed better in the initial latency to the platform location during the probe trial of the Morris Water Maze (MWM) test than SED, but not in any other aspect of MWM or the Novel Object Recognition test. The results of this study indicate that exercise training decreases amyloid plaque load in an intensity dependent manner and that high-intensity exercise training improves cognitive function relative to SED mice, but the intensity of the LOW group was below the threshold to demonstrate robust improvement in cognitive function in Tg2576 mice.https://www.mdpi.com/2076-3425/10/2/88alzheimer’s diseaseexercise trainingamyloid plaquecognitive functiontg2576 mice |
| spellingShingle | Riya Thomas Scott D. Zimmerman Kayla M. Yuede John R. Cirrito Leon M. Tai Benjamin F. Timson Carla M. Yuede Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease Brain Sciences alzheimer’s disease exercise training amyloid plaque cognitive function tg2576 mice |
| title | Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease |
| title_full | Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease |
| title_fullStr | Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease |
| title_full_unstemmed | Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease |
| title_short | Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease |
| title_sort | exercise training results in lower amyloid plaque load and greater cognitive function in an intensity dependent manner in the tg2576 mouse model of alzheimer s disease |
| topic | alzheimer’s disease exercise training amyloid plaque cognitive function tg2576 mice |
| url | https://www.mdpi.com/2076-3425/10/2/88 |
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