Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of coronaviruses, to co...

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Main Authors:	Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Jia-Tsrong Jan, Yi-Ling Lin, Sui-Yuan Chang, Tzu-Ting Peng, Ruey-Bing Yang, Jian-Jong Liang, Chun-Che Liao, Tai-Ling Chao, Yu-Hau Pang, Han-Chieh Kao, Wen-Zheng Huang, Jiunn-Horng Lin, Chun-Ping Chang, Guang-Hao Niu, Szu-Huei Wu, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Pharmacology
Subjects:	HCoV-OC43 HCoV-229E FIPV tylophorine SARS-CoV-2 ouabain
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.606097/full

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