Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy
Objectives The potentially different effects of commonly used anaesthetic agents propofol and sevoflurane on T-cell immune function and Th cell differentiation were investigated in patients with severe mycoplasmal pneumonia (SMPP) undergoing fibreoptic bronchoscopy.Methods Sixty children (2–12 years...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2121416 |
| _version_ | 1798019152940630016 |
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| author | Hui Yu Lin Chen Cheng-Jin Yue Heng Xu Jing Cheng Elyse M. Cornett Alan D. Kaye Ivan Urits Omar Viswanath Henry Liu |
| author_facet | Hui Yu Lin Chen Cheng-Jin Yue Heng Xu Jing Cheng Elyse M. Cornett Alan D. Kaye Ivan Urits Omar Viswanath Henry Liu |
| author_sort | Hui Yu |
| collection | DOAJ |
| description | Objectives The potentially different effects of commonly used anaesthetic agents propofol and sevoflurane on T-cell immune function and Th cell differentiation were investigated in patients with severe mycoplasmal pneumonia (SMPP) undergoing fibreoptic bronchoscopy.Methods Sixty children (2–12 years of age) with SMPP were randomized into the sevoflurane group and the propofol group. Patients in the sevoflurane group were anaesthetised with inhalational sevoflurane and intravenous remifentanil. Patients in the propofol group were anaesthetised with intravenous propofol and remifentanil. Patients in both groups underwent fibreoptic bronchoscopy and lavage therapy. We compared the clinical outcomes, cellular immunity function, and Th cell differentiation into Th1 and Th2 levels in both groups.Results There was no significant difference in clinical outcomes and hospital stay between the two groups (7.94 vs 7.36, p > .05). However, the CD3+ T cells, CD4+ T cells, and CD4+/CD8+ in the propofol group were significantly higher than those in the sevoflurane group (T1 51.96 vs 48.33, T2 58.08 vs 55.31, p < .05). The ratio of Th1/Th2 in the two groups was significantly increased postoperatively in both groups (Sevoflurane 8.53 vs 7.23, Propofol 9.35 vs 7.18), and the propofol group was significantly higher than the sevoflurane group (9.35 vs 8.53, p < .05).Conclusions Propofol might have a less inhibitory effect on T lymphocytes in children with SMPP than sevoflurane. And propofol may have less impact on the differentiation of Th cells into Th1 cells and better preserving the Th1/Th2 ratio than sevoflurane. KEY MESSAGESThe pathogenesis of SMPP is still unclear, likely through alveolar infiltration with neutrophils and lymphocytes, lymphocyte/plasma cell infiltrates in the peri-bronchovascular area, and immune dysfunction.Recent experimental and clinical studies showed that sevoflurane might have immunosuppressive effects, and multiple studies confirmed that the immune function of children with SMPP had been reduced.This study found that propofol administered in children with SMPP had a less inhibitory effect on T lymphocytes than inhalational sevoflurane, had little inhibitory effect on the differentiation of Th cells into Th1 cells, and better preserve Th1/Th2 ratio and maintain the balanced immune function. |
| first_indexed | 2024-04-11T16:36:08Z |
| format | Article |
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| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-11T16:36:08Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-8f314dab04fc41119bd6bbc770e4835f2022-12-22T04:13:50ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-015412574258010.1080/07853890.2022.2121416Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopyHui Yu0Lin Chen1Cheng-Jin Yue2Heng Xu3Jing Cheng4Elyse M. Cornett5Alan D. Kaye6Ivan Urits7Omar Viswanath8Henry Liu9Department of Anesthesiology, Hubei Women and Children’s Hospital, Tongji Medical College, Huazhong University Science & Technology, Wuhan, Hubei, ChinaDepartment of Anesthesiology, Hubei Women and Children’s Hospital, Tongji Medical College, Huazhong University Science & Technology, Wuhan, Hubei, ChinaDepartment of Anesthesiology, Hubei Women and Children’s Hospital, Tongji Medical College, Huazhong University Science & Technology, Wuhan, Hubei, ChinaDepartment of Anesthesiology, Hubei Women and Children’s Hospital, Tongji Medical College, Huazhong University Science & Technology, Wuhan, Hubei, ChinaDepartment of Anesthesiology, Hubei Women and Children’s Hospital, Tongji Medical College, Huazhong University Science & Technology, Wuhan, Hubei, ChinaDepartments of Anesthesiology and Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, Shreveport, LA, USADepartments of Anesthesiology and Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, Shreveport, LA, USADepartments of Anesthesiology and Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, Shreveport, LA, USADepartments of Anesthesiology and Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, Shreveport, LA, USADepartment of Anesthesiology & Perioperative Medicine, Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USAObjectives The potentially different effects of commonly used anaesthetic agents propofol and sevoflurane on T-cell immune function and Th cell differentiation were investigated in patients with severe mycoplasmal pneumonia (SMPP) undergoing fibreoptic bronchoscopy.Methods Sixty children (2–12 years of age) with SMPP were randomized into the sevoflurane group and the propofol group. Patients in the sevoflurane group were anaesthetised with inhalational sevoflurane and intravenous remifentanil. Patients in the propofol group were anaesthetised with intravenous propofol and remifentanil. Patients in both groups underwent fibreoptic bronchoscopy and lavage therapy. We compared the clinical outcomes, cellular immunity function, and Th cell differentiation into Th1 and Th2 levels in both groups.Results There was no significant difference in clinical outcomes and hospital stay between the two groups (7.94 vs 7.36, p > .05). However, the CD3+ T cells, CD4+ T cells, and CD4+/CD8+ in the propofol group were significantly higher than those in the sevoflurane group (T1 51.96 vs 48.33, T2 58.08 vs 55.31, p < .05). The ratio of Th1/Th2 in the two groups was significantly increased postoperatively in both groups (Sevoflurane 8.53 vs 7.23, Propofol 9.35 vs 7.18), and the propofol group was significantly higher than the sevoflurane group (9.35 vs 8.53, p < .05).Conclusions Propofol might have a less inhibitory effect on T lymphocytes in children with SMPP than sevoflurane. And propofol may have less impact on the differentiation of Th cells into Th1 cells and better preserving the Th1/Th2 ratio than sevoflurane. KEY MESSAGESThe pathogenesis of SMPP is still unclear, likely through alveolar infiltration with neutrophils and lymphocytes, lymphocyte/plasma cell infiltrates in the peri-bronchovascular area, and immune dysfunction.Recent experimental and clinical studies showed that sevoflurane might have immunosuppressive effects, and multiple studies confirmed that the immune function of children with SMPP had been reduced.This study found that propofol administered in children with SMPP had a less inhibitory effect on T lymphocytes than inhalational sevoflurane, had little inhibitory effect on the differentiation of Th cells into Th1 cells, and better preserve Th1/Th2 ratio and maintain the balanced immune function.https://www.tandfonline.com/doi/10.1080/07853890.2022.2121416Propofolsevofluraneimmune functionsevere mycoplasmal pneumoniafibreoptic bronchoscopybronchial lavage |
| spellingShingle | Hui Yu Lin Chen Cheng-Jin Yue Heng Xu Jing Cheng Elyse M. Cornett Alan D. Kaye Ivan Urits Omar Viswanath Henry Liu Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy Annals of Medicine Propofol sevoflurane immune function severe mycoplasmal pneumonia fibreoptic bronchoscopy bronchial lavage |
| title | Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy |
| title_full | Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy |
| title_fullStr | Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy |
| title_full_unstemmed | Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy |
| title_short | Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy |
| title_sort | effects of propofol and sevoflurane on t cell immune function and th cell differentiation in children with smpp undergoing fibreoptic bronchoscopy |
| topic | Propofol sevoflurane immune function severe mycoplasmal pneumonia fibreoptic bronchoscopy bronchial lavage |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2121416 |
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