4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS
Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2016-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930393/view |
| _version_ | 1818233636376281088 |
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| author | Olga Tereshina Alexcey Vachev |
| author_facet | Olga Tereshina Alexcey Vachev |
| author_sort | Olga Tereshina |
| collection | DOAJ |
| description | Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery disease.
Purpose: To evaluate influence of discontinuing of statins therapy on occurrence of restenosis in patients after carotid endarterectomy.
Methods: We studied 240 patients after carotid endarterectomy, mean age – 64.4±6.8 years. All the patients were divided into two groups: 1 group comprised 124 patients, who had taken atorvastatin in dose 10–40 mg daily and 2 group – 116 patients who discontinued statins therapy due complication 3 %, poor tolerance 9% or personal reluctance 88%. All the patients also underwent serial standardized ultrasound examination on 1, 3, 6, 12 month during first year after operation and then annually. Mean observation time was 5.6±2.1 years. Significant restenosis carotid artery (more than 70%) was established by standard Doppler velocity criteria.
Results: The significant restenosis of internal carotid artery was found in 2,4% patients with statins therapy and in 7,8% patients without statins. Statins withdrawal increased the incidence of late significant restenosis of internal carotid artery (odd ratio: 3.393 95% confidence interval: 0.895–12.857). Patients with withdrawal of statins had higher wall thickness: 4.3±0.8 against 2.9±0.9 (#1088 p<0,05).
Conclusion: Withdrawal of statins therapy in patients after carotid endarterectomy associated with increasing risk of significant restenosis carotid artery. |
| first_indexed | 2024-12-12T11:25:20Z |
| format | Article |
| id | doaj.art-8f3197e2808946a8979042078cbb31db |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T11:25:20Z |
| publishDate | 2016-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-8f3197e2808946a8979042078cbb31db2022-12-22T00:25:55ZengBMCArtery Research1876-44012016-11-011610.1016/j.artres.2016.10.0214.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSISOlga TereshinaAlexcey VachevBackground: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery disease. Purpose: To evaluate influence of discontinuing of statins therapy on occurrence of restenosis in patients after carotid endarterectomy. Methods: We studied 240 patients after carotid endarterectomy, mean age – 64.4±6.8 years. All the patients were divided into two groups: 1 group comprised 124 patients, who had taken atorvastatin in dose 10–40 mg daily and 2 group – 116 patients who discontinued statins therapy due complication 3 %, poor tolerance 9% or personal reluctance 88%. All the patients also underwent serial standardized ultrasound examination on 1, 3, 6, 12 month during first year after operation and then annually. Mean observation time was 5.6±2.1 years. Significant restenosis carotid artery (more than 70%) was established by standard Doppler velocity criteria. Results: The significant restenosis of internal carotid artery was found in 2,4% patients with statins therapy and in 7,8% patients without statins. Statins withdrawal increased the incidence of late significant restenosis of internal carotid artery (odd ratio: 3.393 95% confidence interval: 0.895–12.857). Patients with withdrawal of statins had higher wall thickness: 4.3±0.8 against 2.9±0.9 (#1088 p<0,05). Conclusion: Withdrawal of statins therapy in patients after carotid endarterectomy associated with increasing risk of significant restenosis carotid artery.https://www.atlantis-press.com/article/125930393/view |
| spellingShingle | Olga Tereshina Alexcey Vachev 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS Artery Research |
| title | 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS |
| title_full | 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS |
| title_fullStr | 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS |
| title_full_unstemmed | 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS |
| title_short | 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS |
| title_sort | 4 2 withdrawal of statins therapy in patients after carotid endarterectomy associated with increasing risk of significant restenosis |
| url | https://www.atlantis-press.com/article/125930393/view |
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