Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery
Abstract Few studies have investigated factors associated with acute postsurgical pain (APSP) trajectories, and whether the APSP trajectory can predict chronic postsurgical pain (CPSP) remains unclear. We aimed to identify the predictors of APSP trajectories in patients undergoing gastrointestinal s...
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| Format: | Article |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10504-5 |
| _version_ | 1828851098872446976 |
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| author | Qing-Ren Liu Yu-Chen Dai Mu-Huo Ji Li-Li Qiu Pan-Miao Liu Xing-Bing Sun Jian-Jun Yang |
| author_facet | Qing-Ren Liu Yu-Chen Dai Mu-Huo Ji Li-Li Qiu Pan-Miao Liu Xing-Bing Sun Jian-Jun Yang |
| author_sort | Qing-Ren Liu |
| collection | DOAJ |
| description | Abstract Few studies have investigated factors associated with acute postsurgical pain (APSP) trajectories, and whether the APSP trajectory can predict chronic postsurgical pain (CPSP) remains unclear. We aimed to identify the predictors of APSP trajectories in patients undergoing gastrointestinal surgery. Moreover, we hypothesised that APSP trajectories were independently associated with CPSP. We conducted a prospective cohort study of 282 patients undergoing gastrointestinal surgery to describe APSP trajectories. Psychological questionnaires were administered 1 day before surgery. Meanwhile, demographic characteristics and perioperative data were collected. Average pain intensity during the first 7 days after surgery was assessed by a numeric rating scale (NRS). Persistent pain intensity was evaluated at 3 and 6 months postoperatively by phone call interview. CPSP was defined as pain at the incision site or surrounding areas of surgery with a pain NRS score ≥ 1 at rest. The intercept and slope were calculated by linear regression using the least squares method. The predictors for the APSP trajectory and CPSP were determined using multiple linear regression and multivariate logistic regression, respectively. Body mass index, morphine milligram equivalent (MME) consumption, preoperative chronic pain and anxiety were predictors of the APSP trajectory intercept. Moreover, MME consumption and preoperative anxiety could independently predict the APSP trajectory slope. The incidence of CPSP at 3 and 6 months was 30.58% and 16.42% respectively. APSP trajectory and age were predictors of CPSP 3 months postoperatively, while female sex and preoperative anxiety were predictive factors of CPSP 6 months postoperatively. Preoperative anxiety and postoperative analgesic consumption can predict APSP trajectory. In addition, pain trajectory was associated with CPSP. Clinicians need to stay alert for these predictors and pay close attention to pain resolution. |
| first_indexed | 2024-12-12T23:25:53Z |
| format | Article |
| id | doaj.art-8f34bb0d9ff84c978685a8182f7ca0b3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T23:25:53Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8f34bb0d9ff84c978685a8182f7ca0b32022-12-22T00:08:05ZengNature PortfolioScientific Reports2045-23222022-04-0112111010.1038/s41598-022-10504-5Predictors and predictive effects of acute pain trajectories after gastrointestinal surgeryQing-Ren Liu0Yu-Chen Dai1Mu-Huo Ji2Li-Li Qiu3Pan-Miao Liu4Xing-Bing Sun5Jian-Jun Yang6Department of Anesthesiology, Xishan People’s Hospital of Wuxi CityDepartment of Anesthesiology, Zhongda Hospital, Medical School, Southeast UniversityDepartment of Anesthesiology, The Second Affiliated Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Zhongda Hospital, Medical School, Southeast UniversityDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Anesthesiology, Xishan People’s Hospital of Wuxi CityDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou UniversityAbstract Few studies have investigated factors associated with acute postsurgical pain (APSP) trajectories, and whether the APSP trajectory can predict chronic postsurgical pain (CPSP) remains unclear. We aimed to identify the predictors of APSP trajectories in patients undergoing gastrointestinal surgery. Moreover, we hypothesised that APSP trajectories were independently associated with CPSP. We conducted a prospective cohort study of 282 patients undergoing gastrointestinal surgery to describe APSP trajectories. Psychological questionnaires were administered 1 day before surgery. Meanwhile, demographic characteristics and perioperative data were collected. Average pain intensity during the first 7 days after surgery was assessed by a numeric rating scale (NRS). Persistent pain intensity was evaluated at 3 and 6 months postoperatively by phone call interview. CPSP was defined as pain at the incision site or surrounding areas of surgery with a pain NRS score ≥ 1 at rest. The intercept and slope were calculated by linear regression using the least squares method. The predictors for the APSP trajectory and CPSP were determined using multiple linear regression and multivariate logistic regression, respectively. Body mass index, morphine milligram equivalent (MME) consumption, preoperative chronic pain and anxiety were predictors of the APSP trajectory intercept. Moreover, MME consumption and preoperative anxiety could independently predict the APSP trajectory slope. The incidence of CPSP at 3 and 6 months was 30.58% and 16.42% respectively. APSP trajectory and age were predictors of CPSP 3 months postoperatively, while female sex and preoperative anxiety were predictive factors of CPSP 6 months postoperatively. Preoperative anxiety and postoperative analgesic consumption can predict APSP trajectory. In addition, pain trajectory was associated with CPSP. Clinicians need to stay alert for these predictors and pay close attention to pain resolution.https://doi.org/10.1038/s41598-022-10504-5 |
| spellingShingle | Qing-Ren Liu Yu-Chen Dai Mu-Huo Ji Li-Li Qiu Pan-Miao Liu Xing-Bing Sun Jian-Jun Yang Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery Scientific Reports |
| title | Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| title_full | Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| title_fullStr | Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| title_full_unstemmed | Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| title_short | Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| title_sort | predictors and predictive effects of acute pain trajectories after gastrointestinal surgery |
| url | https://doi.org/10.1038/s41598-022-10504-5 |
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