Inhibitory potential of polyhydroxylated fullerenes against protein tyrosine phosphatase 1B

Inhibitory potential of polyhydroxylated fullerenes against protein tyrosine phosphatase 1B

Inhibition of PTP1B by polyhydroxylated fullerenes was studied in silico and in vitro. The enzyme kinetics in the presence of polyhydroxy small gap fullerenes showed that reciprocal value of maximum velocity non-linearly increases with increasing the inhibitor concentration. Analysis of the dose-dep...

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Bibliographic Details
Main Authors:	O. L. Kobzar, V. V. Trush, V. Yu. Tanchuk, A. I. Vovk
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2015-08-01
Series:	The Ukrainian Biochemical Journal
Subjects:	fullerenes fullerenols protein tyrosine phosphatase PTP1B
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Kobzar_4-15.pdf

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