Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation
Abstract Despite the widespread applications of electroporation in biotechnology and medicine, monitoring the distribution of deep tissue electrical fields in real-time during treatment continues to pose a challenge. Current medical imaging modalities are unable to monitor electroporation during pul...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Communications Engineering |
| Online Access: | https://doi.org/10.1038/s44172-023-00125-9 |
| _version_ | 1797559412136607744 |
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| author | Yifei Xu Leshan Sun Siqi Wang Yuchen Yan Prabodh Pandey Vitalij Novickij Liangzhong Xiang |
| author_facet | Yifei Xu Leshan Sun Siqi Wang Yuchen Yan Prabodh Pandey Vitalij Novickij Liangzhong Xiang |
| author_sort | Yifei Xu |
| collection | DOAJ |
| description | Abstract Despite the widespread applications of electroporation in biotechnology and medicine, monitoring the distribution of deep tissue electrical fields in real-time during treatment continues to pose a challenge. Current medical imaging modalities are unable to monitor electroporation during pulse delivery. Here we propose a method to use electroacoustic tomography (EAT) to prompt the emission of broadband ultrasound waves via electrical energy deposition. EAT boasts submillimeter resolution at depths reaching 7.5 centimeters and can deliver imaging speeds up to 100 frames per second when paired with an ultrasound array system. We’ve successfully detected EAT signals at electric field strengths ranging from 60 volts per centimeter to several tens of kilovolts per centimeter. This establishes EAT as a potential label-free, high-resolution approach for real-time evaluation of deep tissue electroporation during therapeutic procedures. |
| first_indexed | 2024-03-10T17:45:00Z |
| format | Article |
| id | doaj.art-8f38adedf6df4a13ba7398f0a3967e71 |
| institution | Directory Open Access Journal |
| issn | 2731-3395 |
| language | English |
| last_indexed | 2024-03-10T17:45:00Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Engineering |
| spelling | doaj.art-8f38adedf6df4a13ba7398f0a3967e712023-11-20T09:35:00ZengNature PortfolioCommunications Engineering2731-33952023-10-01211910.1038/s44172-023-00125-9Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporationYifei Xu0Leshan Sun1Siqi Wang2Yuchen Yan3Prabodh Pandey4Vitalij Novickij5Liangzhong Xiang6The Department of Biomedical Engineering, University of CaliforniaThe Department of Biomedical Engineering, University of CaliforniaThe Department of Biomedical Engineering, University of CaliforniaThe Department of Biomedical Engineering, University of CaliforniaThe Department of Radiological Sciences, University of California at IrvineInstitute of High Magnetic Fields, Vilnius Gediminas Technical UniversityThe Department of Biomedical Engineering, University of CaliforniaAbstract Despite the widespread applications of electroporation in biotechnology and medicine, monitoring the distribution of deep tissue electrical fields in real-time during treatment continues to pose a challenge. Current medical imaging modalities are unable to monitor electroporation during pulse delivery. Here we propose a method to use electroacoustic tomography (EAT) to prompt the emission of broadband ultrasound waves via electrical energy deposition. EAT boasts submillimeter resolution at depths reaching 7.5 centimeters and can deliver imaging speeds up to 100 frames per second when paired with an ultrasound array system. We’ve successfully detected EAT signals at electric field strengths ranging from 60 volts per centimeter to several tens of kilovolts per centimeter. This establishes EAT as a potential label-free, high-resolution approach for real-time evaluation of deep tissue electroporation during therapeutic procedures.https://doi.org/10.1038/s44172-023-00125-9 |
| spellingShingle | Yifei Xu Leshan Sun Siqi Wang Yuchen Yan Prabodh Pandey Vitalij Novickij Liangzhong Xiang Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation Communications Engineering |
| title | Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation |
| title_full | Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation |
| title_fullStr | Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation |
| title_full_unstemmed | Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation |
| title_short | Electroacoustic tomography for real-time visualization of electrical field dynamics in deep tissue during electroporation |
| title_sort | electroacoustic tomography for real time visualization of electrical field dynamics in deep tissue during electroporation |
| url | https://doi.org/10.1038/s44172-023-00125-9 |
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