Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms
Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1280853/full |
| _version_ | 1797657266570133504 |
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| author | Ting Zhang Ting Zhang Ting Zhang Jun Li Xi Li Yanjun Liu Yanjun Liu |
| author_facet | Ting Zhang Ting Zhang Ting Zhang Jun Li Xi Li Yanjun Liu Yanjun Liu |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 diabetes. Moreover, IMAT aggravates obesity-related muscle metabolism disorders via secretory factors. Interestingly, researchers have discovered that intermuscular brown adipocytes in rodent models provide new hope for obesity treatment by acting on energy dissipation, which inspired researchers to explore the underlying regulation of IMAT formation. However, the molecular and cellular properties and regulatory processes of IMAT remain debated. Previous studies have suggested that muscle-derived stem/progenitor cells and other adipose tissue progenitors contribute to the development of IMAT. Adipocytes within IMAT exhibit features that are similar to either white adipocytes or uncoupling protein 1 (UCP1)-positive brown adipocytes. Additionally, given the heterogeneity of skeletal muscle, which comprises myofibers, satellite cells, and resident mesenchymal progenitors, it is plausible that interplay between these cellular components actively participate in the regulation of intermuscular adipogenesis. In this context, we review recent studies associated with IMAT to offer insights into the cellular origins, biological properties, and regulatory mechanisms of IMAT. Our aim is to provide novel ideas for the therapeutic strategy of IMAT and the development of new drugs targeting IMAT-related metabolic diseases. |
| first_indexed | 2024-03-11T17:42:04Z |
| format | Article |
| id | doaj.art-8f39076df7394f0b9e2f46b55f75f636 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T17:42:04Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8f39076df7394f0b9e2f46b55f75f6362023-10-18T09:16:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12808531280853Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanismsTing Zhang0Ting Zhang1Ting Zhang2Jun Li3Xi Li4Yanjun Liu5Yanjun Liu6Center of Obesity and Metabolic Diseases, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaCenter of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaMedical Research Center, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaDepartment of Orthopedics, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaInstitute of Life Sciences, Chongqing Medical University, Chongqing, ChinaCenter of Obesity and Metabolic Diseases, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaCenter of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, ChinaIntermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 diabetes. Moreover, IMAT aggravates obesity-related muscle metabolism disorders via secretory factors. Interestingly, researchers have discovered that intermuscular brown adipocytes in rodent models provide new hope for obesity treatment by acting on energy dissipation, which inspired researchers to explore the underlying regulation of IMAT formation. However, the molecular and cellular properties and regulatory processes of IMAT remain debated. Previous studies have suggested that muscle-derived stem/progenitor cells and other adipose tissue progenitors contribute to the development of IMAT. Adipocytes within IMAT exhibit features that are similar to either white adipocytes or uncoupling protein 1 (UCP1)-positive brown adipocytes. Additionally, given the heterogeneity of skeletal muscle, which comprises myofibers, satellite cells, and resident mesenchymal progenitors, it is plausible that interplay between these cellular components actively participate in the regulation of intermuscular adipogenesis. In this context, we review recent studies associated with IMAT to offer insights into the cellular origins, biological properties, and regulatory mechanisms of IMAT. Our aim is to provide novel ideas for the therapeutic strategy of IMAT and the development of new drugs targeting IMAT-related metabolic diseases.https://www.frontiersin.org/articles/10.3389/fendo.2023.1280853/fullintermuscular adipose tissueobesityinsulin resistanceintermuscular adipogenesistherapeutic strategy |
| spellingShingle | Ting Zhang Ting Zhang Ting Zhang Jun Li Xi Li Yanjun Liu Yanjun Liu Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms Frontiers in Endocrinology intermuscular adipose tissue obesity insulin resistance intermuscular adipogenesis therapeutic strategy |
| title | Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms |
| title_full | Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms |
| title_fullStr | Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms |
| title_full_unstemmed | Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms |
| title_short | Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms |
| title_sort | intermuscular adipose tissue in obesity and related disorders cellular origins biological characteristics and regulatory mechanisms |
| topic | intermuscular adipose tissue obesity insulin resistance intermuscular adipogenesis therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1280853/full |
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