A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons
Abstract Background The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune compo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-023-00557-0 |
| _version_ | 1797774294287122432 |
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| author | Jeremy B. Swann Christiane Grammer Michael Schorpp Thomas Boehm |
| author_facet | Jeremy B. Swann Christiane Grammer Michael Schorpp Thomas Boehm |
| author_sort | Jeremy B. Swann |
| collection | DOAJ |
| description | Abstract Background The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune components in two of the five Lophiiformes sub-orders (Lophioidei and Ceratioidei), while no anomalies have been identified to date in two other sub-orders, Antennaroidei and Chaunacoidei. The immunogenome of the fifth sub-order, Ogcocephaloidei has not yet been investigated, and we have therefore used whole genome shotgun sequencing, combined with RNA-seq, to survey the adaptive immune capabilities of the polka-dot batfish, O. cubifrons, as a representative of this as yet unexplored sub-order. Results We find that the O. cubifrons genome encodes the core genes needed to mount adaptive T and B cell responses. These genes include those necessary for rearranging and editing antigen receptors, the antigen receptors themselves; as well as the co-receptors, signalling molecules, and antigen presenting molecules (both class I and class II) needed for B cell and T cell development and activation. Conclusions From an immune perspective, the polka-dot batfish has a canonical complement of adaptive immune genes, and does not exhibit any of the adaptive immune changes previously identified in monkfish and oceanic anglerfish. |
| first_indexed | 2024-03-12T22:18:56Z |
| format | Article |
| id | doaj.art-8f3be333bddb4ee69b1c130c61d2d04b |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-03-12T22:18:56Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-8f3be333bddb4ee69b1c130c61d2d04b2023-07-23T11:10:29ZengBMCBMC Immunology1471-21722023-07-0124111210.1186/s12865-023-00557-0A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifronsJeremy B. Swann0Christiane Grammer1Michael Schorpp2Thomas Boehm3Department of Developmental Immunology, Max Planck-Institute of Immunobiology and EpigeneticsDepartment of Developmental Immunology, Max Planck-Institute of Immunobiology and EpigeneticsDepartment of Developmental Immunology, Max Planck-Institute of Immunobiology and EpigeneticsDepartment of Developmental Immunology, Max Planck-Institute of Immunobiology and EpigeneticsAbstract Background The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune components in two of the five Lophiiformes sub-orders (Lophioidei and Ceratioidei), while no anomalies have been identified to date in two other sub-orders, Antennaroidei and Chaunacoidei. The immunogenome of the fifth sub-order, Ogcocephaloidei has not yet been investigated, and we have therefore used whole genome shotgun sequencing, combined with RNA-seq, to survey the adaptive immune capabilities of the polka-dot batfish, O. cubifrons, as a representative of this as yet unexplored sub-order. Results We find that the O. cubifrons genome encodes the core genes needed to mount adaptive T and B cell responses. These genes include those necessary for rearranging and editing antigen receptors, the antigen receptors themselves; as well as the co-receptors, signalling molecules, and antigen presenting molecules (both class I and class II) needed for B cell and T cell development and activation. Conclusions From an immune perspective, the polka-dot batfish has a canonical complement of adaptive immune genes, and does not exhibit any of the adaptive immune changes previously identified in monkfish and oceanic anglerfish.https://doi.org/10.1186/s12865-023-00557-0AnglerfishBatfishAdaptive immunityImmune evolution |
| spellingShingle | Jeremy B. Swann Christiane Grammer Michael Schorpp Thomas Boehm A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons BMC Immunology Anglerfish Batfish Adaptive immunity Immune evolution |
| title | A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons |
| title_full | A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons |
| title_fullStr | A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons |
| title_full_unstemmed | A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons |
| title_short | A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons |
| title_sort | survey of the adaptive immune genes of the polka dot batfish ogcocephalus cubifrons |
| topic | Anglerfish Batfish Adaptive immunity Immune evolution |
| url | https://doi.org/10.1186/s12865-023-00557-0 |
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