Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage. Thus, treatment with galunisertib, a small molecule inhibitor of TGFβ recept...

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Chi tiết về thư mục
Những tác giả chính: Matthis Desoteux, Betty Maillot, Kevin Bévant, Tanguy Ferlier, Raffaële Leroux, Gaëlle Angenard, Corentin Louis, Laurent Sulpice, Karim Boudjema, Cédric Coulouarn
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Wiley 2023-07-01
Loạt:FEBS Open Bio
Những chủ đề:
galunisertib
gene signature
hepatocellular carcinoma
survival
TGFβ
Truy cập trực tuyến:https://doi.org/10.1002/2211-5463.13647

Internet

https://doi.org/10.1002/2211-5463.13647

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