Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Transcriptomic evidence for tumor‐specific beneficial or adverse effects of TGFβ pathway inhibition on the prognosis of patients with liver cancer

Therapeutic targeting of the transforming growth factor beta (TGFβ) pathway in cancer represents a clinical challenge since TGFβ exhibits either tumor suppressive or tumor promoting properties, depending on the tumor stage. Thus, treatment with galunisertib, a small molecule inhibitor of TGFβ recept...

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Bibliographic Details
Main Authors: Matthis Desoteux, Betty Maillot, Kevin Bévant, Tanguy Ferlier, Raffaële Leroux, Gaëlle Angenard, Corentin Louis, Laurent Sulpice, Karim Boudjema, Cédric Coulouarn
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:FEBS Open Bio
Subjects:
galunisertib
gene signature
hepatocellular carcinoma
survival
TGFβ
Online Access:https://doi.org/10.1002/2211-5463.13647

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