Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient
Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib. Tumor lysis syndrome induced by low-dose steroid...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2015-03-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-21-85.pdf |
| _version_ | 1818550274135949312 |
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| author | Jin Ok Kim Dae Won Jun Hye Jin Tae Kang Nyeong Lee Hang Lak Lee Oh Young Lee Ho Soon Choi Byung Chul Yoon Joon Soo Hahm |
| author_facet | Jin Ok Kim Dae Won Jun Hye Jin Tae Kang Nyeong Lee Hang Lak Lee Oh Young Lee Ho Soon Choi Byung Chul Yoon Joon Soo Hahm |
| author_sort | Jin Ok Kim |
| collection | DOAJ |
| description | Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib. Tumor lysis syndrome induced by low-dose steroid appears to be very unusual in HCC. We report a patient with hepatitis-C-related liver cirrhosis and HCC in whom tumor lysis syndrome occurred due to low-dose steroid (10 mg of prednisolone). The patient was a 90-year-old male who presented at the emergency room of our hospital with general weakness and poor oral intake. He had started to take prednisolone to treat adrenal insufficiency 2 days previously. Laboratory results revealed hyperuricemia, hyperphosphatemia, and increased creatinine. These abnormalities fulfilled the criteria in the Cairo-Bishop definition of tumor lysis syndrome. Although the patient received adequate hydration, severe metabolic acidosis and acute kidney injury progressed unabated. He finally developed multiple organ failure, and died 3 days after admission. This was a case of tumor lysis syndrome caused by administration of low-dose steroid in a patient with HCC. |
| first_indexed | 2024-12-12T08:44:15Z |
| format | Article |
| id | doaj.art-8f3cf25d43ae4757b53d6a35134dc642 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-12T08:44:15Z |
| publishDate | 2015-03-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-8f3cf25d43ae4757b53d6a35134dc6422022-12-22T00:30:39ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2015-03-01211858810.3350/cmh.2015.21.1.851176Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patientJin Ok Kim0Dae Won Jun1Hye Jin Tae2Kang Nyeong Lee3Hang Lak Lee4Oh Young Lee5Ho Soon Choi6Byung Chul Yoon7Joon Soo Hahm8Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib. Tumor lysis syndrome induced by low-dose steroid appears to be very unusual in HCC. We report a patient with hepatitis-C-related liver cirrhosis and HCC in whom tumor lysis syndrome occurred due to low-dose steroid (10 mg of prednisolone). The patient was a 90-year-old male who presented at the emergency room of our hospital with general weakness and poor oral intake. He had started to take prednisolone to treat adrenal insufficiency 2 days previously. Laboratory results revealed hyperuricemia, hyperphosphatemia, and increased creatinine. These abnormalities fulfilled the criteria in the Cairo-Bishop definition of tumor lysis syndrome. Although the patient received adequate hydration, severe metabolic acidosis and acute kidney injury progressed unabated. He finally developed multiple organ failure, and died 3 days after admission. This was a case of tumor lysis syndrome caused by administration of low-dose steroid in a patient with HCC.http://e-cmh.org/upload/pdf/cmh-21-85.pdfTumor lysis syndromeHepatocellular carcinomaSteroid |
| spellingShingle | Jin Ok Kim Dae Won Jun Hye Jin Tae Kang Nyeong Lee Hang Lak Lee Oh Young Lee Ho Soon Choi Byung Chul Yoon Joon Soo Hahm Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient Clinical and Molecular Hepatology Tumor lysis syndrome Hepatocellular carcinoma Steroid |
| title | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| title_full | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| title_fullStr | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| title_full_unstemmed | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| title_short | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| title_sort | low dose steroid induced tumor lysis syndrome in a hepatocellular carcinoma patient |
| topic | Tumor lysis syndrome Hepatocellular carcinoma Steroid |
| url | http://e-cmh.org/upload/pdf/cmh-21-85.pdf |
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