Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

PLP overexpressing mice display demyelination and axonopathic changes, accompanied by an elevation of CD8+ T-lymphocytes and CD11b+ macrophages in the CNS. By crossbreeding these mutants with RAG-1-deficient mice lacking mature lymphocytes, we could recently demonstrate a pathogenetic impact of the...

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Bibliographic Details
Main Authors: Chi Wang Ip, Antje Kroner, Paul R. Crocker, Klaus-Armin Nave, Rudolf Martini
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neurobiology of Disease
Subjects:
Microglia
Macrophages
T-lymphocytes
Leukodystrophy
Multiple sclerosis
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002166

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