Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment
Abstract The post‐charging antibacterial therapy is highly promising for treatment of Gram‐negative bacterial wound infections. However, the therapeutic efficacy of the current electrode materials is yet unsatisfactory due to their low charge storage capacity and limited reactive oxygen species (ROS...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202207594 |
| _version_ | 1797851993338806272 |
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| author | Xianshuo Cao Zongshao Li Fan Yang Jinhao Xie Xin Shi Peiyan Yuan Xin Ding Xihong Lu |
| author_facet | Xianshuo Cao Zongshao Li Fan Yang Jinhao Xie Xin Shi Peiyan Yuan Xin Ding Xihong Lu |
| author_sort | Xianshuo Cao |
| collection | DOAJ |
| description | Abstract The post‐charging antibacterial therapy is highly promising for treatment of Gram‐negative bacterial wound infections. However, the therapeutic efficacy of the current electrode materials is yet unsatisfactory due to their low charge storage capacity and limited reactive oxygen species (ROS) yields. Herein, the design of MnOOH decorated Co3O4 nanoneedles (MCO) with exceptional post‐charging antibacterial effect against Gram‐negative bacteria at a low charge voltage and their implementation as a robust antibacterial electrode for skin wound treatment are reported. Taking advantaging of the increased active sites and enhanced OH− adsorption capability, the charge storage capacity and ROS production of the MCO electrode are remarkably boosted. As a result, the MCO electrode after charging at an ultralow voltage of 1.4 V gives a 5.49 log and 5.82 log bacterial reduction in Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) within an incubation time of only 5 min, respectively. More importantly, the antibacterial efficiency of the MCO electrode against multi‐drug resistant (MDR) bacteria including Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) also reaches 99.999%. In addition, the MCO electrode exhibits excellent reusability, and the role of extracellular ROS in enhancing post‐charging antibacterial activity is also unraveled. |
| first_indexed | 2024-04-09T19:26:50Z |
| format | Article |
| id | doaj.art-8f404ac753d64c308a0ae03ca2cdf4f3 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T19:26:50Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-8f404ac753d64c308a0ae03ca2cdf4f32023-04-05T08:09:48ZengWileyAdvanced Science2198-38442023-04-011010n/an/a10.1002/advs.202207594Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection TreatmentXianshuo Cao0Zongshao Li1Fan Yang2Jinhao Xie3Xin Shi4Peiyan Yuan5Xin Ding6Xihong Lu7School of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaSchool of Chemistry School of Pharmaceutical Sciences (Shenzhen) The Key Lab of Low‐carbon Chem & Energy Conservation of Guangdong Province Sun Yat‐Sen University Guangzhou 510275 P. R. ChinaAbstract The post‐charging antibacterial therapy is highly promising for treatment of Gram‐negative bacterial wound infections. However, the therapeutic efficacy of the current electrode materials is yet unsatisfactory due to their low charge storage capacity and limited reactive oxygen species (ROS) yields. Herein, the design of MnOOH decorated Co3O4 nanoneedles (MCO) with exceptional post‐charging antibacterial effect against Gram‐negative bacteria at a low charge voltage and their implementation as a robust antibacterial electrode for skin wound treatment are reported. Taking advantaging of the increased active sites and enhanced OH− adsorption capability, the charge storage capacity and ROS production of the MCO electrode are remarkably boosted. As a result, the MCO electrode after charging at an ultralow voltage of 1.4 V gives a 5.49 log and 5.82 log bacterial reduction in Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) within an incubation time of only 5 min, respectively. More importantly, the antibacterial efficiency of the MCO electrode against multi‐drug resistant (MDR) bacteria including Klebsiella pneumoniae (K. pneumoniae) and Acinetobacter baumannii (A. baumannii) also reaches 99.999%. In addition, the MCO electrode exhibits excellent reusability, and the role of extracellular ROS in enhancing post‐charging antibacterial activity is also unraveled.https://doi.org/10.1002/advs.202207594antibacterial electrodelow charge voltagepost‐charging antibacterialreactive oxygen specieswound infections |
| spellingShingle | Xianshuo Cao Zongshao Li Fan Yang Jinhao Xie Xin Shi Peiyan Yuan Xin Ding Xihong Lu Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment Advanced Science antibacterial electrode low charge voltage post‐charging antibacterial reactive oxygen species wound infections |
| title | Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment |
| title_full | Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment |
| title_fullStr | Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment |
| title_full_unstemmed | Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment |
| title_short | Ultralow Charge Voltage Triggering Exceptional Post‐Charging Antibacterial Capability of Co3O4/MnOOH Nanoneedles for Skin Infection Treatment |
| title_sort | ultralow charge voltage triggering exceptional post charging antibacterial capability of co3o4 mnooh nanoneedles for skin infection treatment |
| topic | antibacterial electrode low charge voltage post‐charging antibacterial reactive oxygen species wound infections |
| url | https://doi.org/10.1002/advs.202207594 |
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