Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia

Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia

Abstract Background Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration of stem cells may affect endogenous mechanisms that regulate ADMA produc...

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Bibliographic Details
Main Authors: Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik, Ivan Vulev
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Stem Cell Research & Therapy
Subjects:
Cell therapy
Oxidative stress
Asymmetric dimethylarginine
Angiogenesis
Critical limb ischemia
Online Access:http://link.springer.com/article/10.1186/s13287-017-0622-2

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