Fine-Tuning of Type I Interferon Response by STAT3

Fine-Tuning of Type I Interferon Response by STAT3

Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation. STAT1, STAT2, and IRF9 form ISGF3 complex which transactivates downst...

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Bibliographic Details
Main Authors: Ming-Hsun Tsai, Li-Mei Pai, Chien-Kuo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
type I interferon (IFN-I)
STAT3
phospholipid scramblase 2
antiviral immunity
SOCS3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01448/full

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