The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate
The effect of nanosilica on the microstructure setting process of tetracalcium phosphate/nanomonetite calcium phosphate cement mixture (CPC) with the addition of 5 wt% of magnesium pyrophosphate (assigned as CT5MP) and osteogenic differentiation of mesenchymal stem cells cultured in cement extracts...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/1996-1944/15/22/8212 |
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| author | Radoslava Stulajterova Maria Giretova Lubomir Medvecky Tibor Sopcak Lenka Luptakova Vladimir Girman |
| author_facet | Radoslava Stulajterova Maria Giretova Lubomir Medvecky Tibor Sopcak Lenka Luptakova Vladimir Girman |
| author_sort | Radoslava Stulajterova |
| collection | DOAJ |
| description | The effect of nanosilica on the microstructure setting process of tetracalcium phosphate/nanomonetite calcium phosphate cement mixture (CPC) with the addition of 5 wt% of magnesium pyrophosphate (assigned as CT5MP) and osteogenic differentiation of mesenchymal stem cells cultured in cement extracts were studied. A more compact microstructure was observed in CT5MP cement with 0.5 wt% addition of nanosilica (CT5MP1Si) due to the synergistic effect of Mg<sub>2</sub>P<sub>2</sub>O<sub>7</sub> particles, which strengthened the cement matrix and nanosilica, which supported gradual growth and recrystallization of HAP particles to form compact agglomerates. The addition of 0.5 wt% of nanosilica to CT5MP cement caused an increase in CS from 18 to 24 MPa while the setting time increased almost twofold. It was verified that adding nanosilica to CPC cement, even in a low amount (0.5 and 1 wt% of nanosilica), positively affected the injectability of cement pastes and differentiation of cells with upregulation of osteogenic markers in cells cultured in cement extracts. Results revealed appropriate properties of these types of cement for filling bone defects. |
| first_indexed | 2024-03-09T18:11:56Z |
| format | Article |
| id | doaj.art-8f44aa9c9172426090ad68df3ab353c4 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T18:11:56Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-8f44aa9c9172426090ad68df3ab353c42023-11-24T09:06:00ZengMDPI AGMaterials1996-19442022-11-011522821210.3390/ma15228212The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium PyrophoshateRadoslava Stulajterova0Maria Giretova1Lubomir Medvecky2Tibor Sopcak3Lenka Luptakova4Vladimir Girman5Division of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaDepartment of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaThe effect of nanosilica on the microstructure setting process of tetracalcium phosphate/nanomonetite calcium phosphate cement mixture (CPC) with the addition of 5 wt% of magnesium pyrophosphate (assigned as CT5MP) and osteogenic differentiation of mesenchymal stem cells cultured in cement extracts were studied. A more compact microstructure was observed in CT5MP cement with 0.5 wt% addition of nanosilica (CT5MP1Si) due to the synergistic effect of Mg<sub>2</sub>P<sub>2</sub>O<sub>7</sub> particles, which strengthened the cement matrix and nanosilica, which supported gradual growth and recrystallization of HAP particles to form compact agglomerates. The addition of 0.5 wt% of nanosilica to CT5MP cement caused an increase in CS from 18 to 24 MPa while the setting time increased almost twofold. It was verified that adding nanosilica to CPC cement, even in a low amount (0.5 and 1 wt% of nanosilica), positively affected the injectability of cement pastes and differentiation of cells with upregulation of osteogenic markers in cells cultured in cement extracts. Results revealed appropriate properties of these types of cement for filling bone defects.https://www.mdpi.com/1996-1944/15/22/8212hydroxyapatite compositenanosilicamagnesium pyrophosphatesetting processmesenchymal stem cells |
| spellingShingle | Radoslava Stulajterova Maria Giretova Lubomir Medvecky Tibor Sopcak Lenka Luptakova Vladimir Girman The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate Materials hydroxyapatite composite nanosilica magnesium pyrophosphate setting process mesenchymal stem cells |
| title | The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate |
| title_full | The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate |
| title_fullStr | The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate |
| title_full_unstemmed | The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate |
| title_short | The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate |
| title_sort | influence of nanosilica on properties of cement based on tetracalcium phosphate monetite mixture with addition of magnesium pyrophoshate |
| topic | hydroxyapatite composite nanosilica magnesium pyrophosphate setting process mesenchymal stem cells |
| url | https://www.mdpi.com/1996-1944/15/22/8212 |
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