Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma

Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma

The purpose of this study was to investigate the effects of valdecoxib on the retina in retinal ischemia-reperfusion injury (IRI) and R28 cells following oxygen-glucose deprivation/recovery (OGD/R) injury, as well as the underlying mechanisms. Immunofluorescence and Cell Counting Kit-8 (CCK-8) analy...

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Bibliographic Details
Main Authors: Zhaolin Gao, Min Li, Fei Yao, Xiaobo Xia, Tianqi Duan, Jingzhuo Meng, Yanxia Huang, Ye He, Adonira Saro, Jufang Huang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
valdecoxib
glaucoma
ER stress
apoptosis
Online Access:https://www.mdpi.com/1422-0067/23/21/12983

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https://www.mdpi.com/1422-0067/23/21/12983

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