Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring
Abstract Continuous glucose monitoring systems (CGMS) are becoming increasingly popular in diabetes management compared to conventional methods of self-blood glucose monitoring systems. They help understanding physiological responses towards nutrition intake, physical activities in everyday life and...
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-22128-w |
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author | Seongmun Kim Jagannath Malik Jong Mo Seo Young Min Cho Franklin Bien |
author_facet | Seongmun Kim Jagannath Malik Jong Mo Seo Young Min Cho Franklin Bien |
author_sort | Seongmun Kim |
collection | DOAJ |
description | Abstract Continuous glucose monitoring systems (CGMS) are becoming increasingly popular in diabetes management compared to conventional methods of self-blood glucose monitoring systems. They help understanding physiological responses towards nutrition intake, physical activities in everyday life and glucose control. CGMS available in market are of two types based on their working principle. Needle type systems with few weeks lifespan (e.g., enzyme-based Freestyle Libre) and implant type system (e.g., fluorescence-based Senseonics) with few months of lifespan are commercially available. An alternate to both working methods, herein, we propose electromagnetic-based sensor that can be subcutaneously implanted and capable of tracking minute changes in dielectric permittivity owing to changes in blood glucose level (BGL). Proof-of-concept of proposed electromagnetic-based implant sensor has been validated in intravenous glucose tolerance test (IVGTT) conducted on swine and beagle in a controlled environment. Sensor interface modules, mobile applications, and glucose mapping algorithms are also developed for continuous measurement in a freely moving beagle during oral glucose tolerance test (OGTT). The results of the short-term (1 h, IVGTT) and long-term (52 h, OGTT) test are summarized in this work. A close trend is observed between sensor frequency and BGL during GTT experiments on both animal species. |
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id | doaj.art-8f468d2214bb496197f06106223a0f43 |
institution | Directory Open Access Journal |
issn | 2045-2322 |
language | English |
last_indexed | 2024-04-12T15:57:21Z |
publishDate | 2022-10-01 |
publisher | Nature Portfolio |
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series | Scientific Reports |
spelling | doaj.art-8f468d2214bb496197f06106223a0f432022-12-22T03:26:18ZengNature PortfolioScientific Reports2045-23222022-10-0112111110.1038/s41598-022-22128-wSubcutaneously implantable electromagnetic biosensor system for continuous glucose monitoringSeongmun Kim0Jagannath Malik1Jong Mo Seo2Young Min Cho3Franklin Bien4Department of Electrical Engineering, Ulsan National Institute of Science and TechnologySB Solutions Inc.Department of Electrical and Computer Engineering, Seoul National UniversityDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Electrical Engineering, Ulsan National Institute of Science and TechnologyAbstract Continuous glucose monitoring systems (CGMS) are becoming increasingly popular in diabetes management compared to conventional methods of self-blood glucose monitoring systems. They help understanding physiological responses towards nutrition intake, physical activities in everyday life and glucose control. CGMS available in market are of two types based on their working principle. Needle type systems with few weeks lifespan (e.g., enzyme-based Freestyle Libre) and implant type system (e.g., fluorescence-based Senseonics) with few months of lifespan are commercially available. An alternate to both working methods, herein, we propose electromagnetic-based sensor that can be subcutaneously implanted and capable of tracking minute changes in dielectric permittivity owing to changes in blood glucose level (BGL). Proof-of-concept of proposed electromagnetic-based implant sensor has been validated in intravenous glucose tolerance test (IVGTT) conducted on swine and beagle in a controlled environment. Sensor interface modules, mobile applications, and glucose mapping algorithms are also developed for continuous measurement in a freely moving beagle during oral glucose tolerance test (OGTT). The results of the short-term (1 h, IVGTT) and long-term (52 h, OGTT) test are summarized in this work. A close trend is observed between sensor frequency and BGL during GTT experiments on both animal species.https://doi.org/10.1038/s41598-022-22128-w |
spellingShingle | Seongmun Kim Jagannath Malik Jong Mo Seo Young Min Cho Franklin Bien Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring Scientific Reports |
title | Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
title_full | Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
title_fullStr | Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
title_full_unstemmed | Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
title_short | Subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
title_sort | subcutaneously implantable electromagnetic biosensor system for continuous glucose monitoring |
url | https://doi.org/10.1038/s41598-022-22128-w |
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