Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer
Abstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, end...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-021-02434-9 |
| _version_ | 1798033180546039808 |
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| author | Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao |
| author_facet | Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao |
| author_sort | Atsushi Ito |
| collection | DOAJ |
| description | Abstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, endobronchial brachytherapy (EBBT) plays an important role not only as a palliative treatment, but also as a definitive treatment with curative intent. Case presentation Three men (64, 69, and 74 years old) underwent combination therapy of external beam radiation therapy (EBRT) and EBBT for endobronchial metastasis after lobectomy of stage I–II non-small cell lung cancer (NSCLC): 2 cases of squamous cell carcinoma and 1 of adenocarcinoma. We used a special source-centralizing applicator for EBBT to avoid eccentric distribution of the radiation dose. Follow-up was considered to start from the end of brachytherapy. None of our patients experienced severe adverse events, and none needed extensive outpatient treatment. Local control was achieved in all cases by a bronchoscopic evaluation. All patients were alive after 31, 38, and 92 months of follow-up, respectively. In the adenocarcinoma patient, two metastases to the lung were discovered 3 years after EBBT, and the patient underwent partial wedge resection. Conclusions EBBT may be a promising treatment with curative intent for endobronchial metastasis after surgery of NSCLC. |
| first_indexed | 2024-04-11T20:26:10Z |
| format | Article |
| id | doaj.art-8f46a6e280dd4cdf88aac13a6f2a6faa |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-11T20:26:10Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-8f46a6e280dd4cdf88aac13a6f2a6faa2022-12-22T04:04:40ZengBMCWorld Journal of Surgical Oncology1477-78192021-11-011911510.1186/s12957-021-02434-9Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancerAtsushi Ito0Daisuke Yamaguchi1Shinji Kaneda2Koji Kawaguchi3Akira Shimamoto4Makiko Kubooka5Yoshihito Nomoto6Motoshi Takao7Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityDepartment of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityDepartment of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityDepartment of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityDepartment of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityDepartment of Radiology, Graduate School of Medicine, Mie UniversityDepartment of Radiation Oncology, Graduate School of Medicine, Mie UniversityDepartment of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, Mie UniversityAbstract Background Endobronchial metastasis is a very rare type of recurrence after lung cancer surgery. Surgical intervention may be difficult to perform due to the postoperative reduction in the activities of daily living (ADL) and the invasiveness associated with redo surgery. In such cases, endobronchial brachytherapy (EBBT) plays an important role not only as a palliative treatment, but also as a definitive treatment with curative intent. Case presentation Three men (64, 69, and 74 years old) underwent combination therapy of external beam radiation therapy (EBRT) and EBBT for endobronchial metastasis after lobectomy of stage I–II non-small cell lung cancer (NSCLC): 2 cases of squamous cell carcinoma and 1 of adenocarcinoma. We used a special source-centralizing applicator for EBBT to avoid eccentric distribution of the radiation dose. Follow-up was considered to start from the end of brachytherapy. None of our patients experienced severe adverse events, and none needed extensive outpatient treatment. Local control was achieved in all cases by a bronchoscopic evaluation. All patients were alive after 31, 38, and 92 months of follow-up, respectively. In the adenocarcinoma patient, two metastases to the lung were discovered 3 years after EBBT, and the patient underwent partial wedge resection. Conclusions EBBT may be a promising treatment with curative intent for endobronchial metastasis after surgery of NSCLC.https://doi.org/10.1186/s12957-021-02434-9Endobronchial metastasisEndobronchial brachytherapyDefinitive treatment |
| spellingShingle | Atsushi Ito Daisuke Yamaguchi Shinji Kaneda Koji Kawaguchi Akira Shimamoto Makiko Kubooka Yoshihito Nomoto Motoshi Takao Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer World Journal of Surgical Oncology Endobronchial metastasis Endobronchial brachytherapy Definitive treatment |
| title | Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer |
| title_full | Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer |
| title_fullStr | Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer |
| title_full_unstemmed | Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer |
| title_short | Endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non-small cell lung cancer |
| title_sort | endobronchial brachytherapy as definitive treatment for endobronchial metastasis after surgery of non small cell lung cancer |
| topic | Endobronchial metastasis Endobronchial brachytherapy Definitive treatment |
| url | https://doi.org/10.1186/s12957-021-02434-9 |
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