Enlarged Perivascular Spaces and Age-Related Clinical Diseases
Yuyuan Yang,1 Meng Wang,1 Moxin Luan,1 Xiaoqian Song,1 Yajuan Wang,2 Lulu Xu,3 Meixiang Zhong,4 Xueping Zheng1 1Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Geriatric Medicine, The Qingdao Eighth People’s Hospita...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-05-01
|
| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/enlarged-perivascular-spaces-and-age-related-clinical-diseases-peer-reviewed-fulltext-article-CIA |
| _version_ | 1797816406963650560 |
|---|---|
| author | Yang Y Wang M Luan M Song X Wang Y Xu L Zhong M Zheng X |
| author_facet | Yang Y Wang M Luan M Song X Wang Y Xu L Zhong M Zheng X |
| author_sort | Yang Y |
| collection | DOAJ |
| description | Yuyuan Yang,1 Meng Wang,1 Moxin Luan,1 Xiaoqian Song,1 Yajuan Wang,2 Lulu Xu,3 Meixiang Zhong,4 Xueping Zheng1 1Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Geriatric Medicine, The Qingdao Eighth People’s Hospital, Qingdao, People’s Republic of China; 3Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 4Department of Geriatric Medicine, The Chengdu Eighth People’s Hospital, Chengdu, People’s Republic of ChinaCorrespondence: Xueping Zheng, Email simplexueping@163.comAbstract: Perivascular spaces are the fluid-filled areas surrounding small blood vessels in the brain, and they may play a role similar to lymphatic vessels in clearing metabolic waste. When their diameters exceed 1 mm, as measured by structural magnetic resonance imaging, they are classified as enlarged perivascular spaces (EPVS). Previously, EPVS were considered to be benign, but increasing evidence suggests that their existence may be associated with various clinical diseases. Here, we review recent clinical studies to understand the potential clinical implications of EPVS. We also review the anatomy and imaging characteristics of EPVS and discuss four causal hypotheses for their formation and associated risk factors. Due to differences in research methods and concerns across studies, unified conclusions are difficult to achieve. Overall, more basic high-quality research is needed to clarify the subject and provide more concrete theoretical support.Keywords: cerebral small vessels, enlarged perivascular spaces, cognitive decline, cerebral amyloid angiopathy, Parkinson’s disease, aging |
| first_indexed | 2024-03-13T08:37:10Z |
| format | Article |
| id | doaj.art-8f4c00194c4b433db25f0e03ce34ad07 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-03-13T08:37:10Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-8f4c00194c4b433db25f0e03ce34ad072023-05-30T19:13:36ZengDove Medical PressClinical Interventions in Aging1178-19982023-05-01Volume 1885586784065Enlarged Perivascular Spaces and Age-Related Clinical DiseasesYang YWang MLuan MSong XWang YXu LZhong MZheng XYuyuan Yang,1 Meng Wang,1 Moxin Luan,1 Xiaoqian Song,1 Yajuan Wang,2 Lulu Xu,3 Meixiang Zhong,4 Xueping Zheng1 1Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Geriatric Medicine, The Qingdao Eighth People’s Hospital, Qingdao, People’s Republic of China; 3Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 4Department of Geriatric Medicine, The Chengdu Eighth People’s Hospital, Chengdu, People’s Republic of ChinaCorrespondence: Xueping Zheng, Email simplexueping@163.comAbstract: Perivascular spaces are the fluid-filled areas surrounding small blood vessels in the brain, and they may play a role similar to lymphatic vessels in clearing metabolic waste. When their diameters exceed 1 mm, as measured by structural magnetic resonance imaging, they are classified as enlarged perivascular spaces (EPVS). Previously, EPVS were considered to be benign, but increasing evidence suggests that their existence may be associated with various clinical diseases. Here, we review recent clinical studies to understand the potential clinical implications of EPVS. We also review the anatomy and imaging characteristics of EPVS and discuss four causal hypotheses for their formation and associated risk factors. Due to differences in research methods and concerns across studies, unified conclusions are difficult to achieve. Overall, more basic high-quality research is needed to clarify the subject and provide more concrete theoretical support.Keywords: cerebral small vessels, enlarged perivascular spaces, cognitive decline, cerebral amyloid angiopathy, Parkinson’s disease, aginghttps://www.dovepress.com/enlarged-perivascular-spaces-and-age-related-clinical-diseases-peer-reviewed-fulltext-article-CIAcerebral small vesselsenlarged perivascular spacescognitive declinecerebral amyloid angiopathyparkinson's diseaseaging |
| spellingShingle | Yang Y Wang M Luan M Song X Wang Y Xu L Zhong M Zheng X Enlarged Perivascular Spaces and Age-Related Clinical Diseases Clinical Interventions in Aging cerebral small vessels enlarged perivascular spaces cognitive decline cerebral amyloid angiopathy parkinson's disease aging |
| title | Enlarged Perivascular Spaces and Age-Related Clinical Diseases |
| title_full | Enlarged Perivascular Spaces and Age-Related Clinical Diseases |
| title_fullStr | Enlarged Perivascular Spaces and Age-Related Clinical Diseases |
| title_full_unstemmed | Enlarged Perivascular Spaces and Age-Related Clinical Diseases |
| title_short | Enlarged Perivascular Spaces and Age-Related Clinical Diseases |
| title_sort | enlarged perivascular spaces and age related clinical diseases |
| topic | cerebral small vessels enlarged perivascular spaces cognitive decline cerebral amyloid angiopathy parkinson's disease aging |
| url | https://www.dovepress.com/enlarged-perivascular-spaces-and-age-related-clinical-diseases-peer-reviewed-fulltext-article-CIA |
| work_keys_str_mv | AT yangy enlargedperivascularspacesandagerelatedclinicaldiseases AT wangm enlargedperivascularspacesandagerelatedclinicaldiseases AT luanm enlargedperivascularspacesandagerelatedclinicaldiseases AT songx enlargedperivascularspacesandagerelatedclinicaldiseases AT wangy enlargedperivascularspacesandagerelatedclinicaldiseases AT xul enlargedperivascularspacesandagerelatedclinicaldiseases AT zhongm enlargedperivascularspacesandagerelatedclinicaldiseases AT zhengx enlargedperivascularspacesandagerelatedclinicaldiseases |