Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies
Background: The purpose of this systematic literature review (SLR) was to evaluate the accuracy of noninvasive diagnostic tools in detecting significant or advanced (F2/F3) fibrosis among patients with nonalcoholic fatty liver (NAFL) in the US healthcare context. Methods: The SLR was conducted in Pu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2608 |
| _version_ | 1797468583345782784 |
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| author | Dhaval Gosalia Vlad Ratziu Filip Stanicic Djurdja Vukicevic Vladimir Zah Nadege Gunn Dina Halegoua-DeMarzio Tram Tran |
| author_facet | Dhaval Gosalia Vlad Ratziu Filip Stanicic Djurdja Vukicevic Vladimir Zah Nadege Gunn Dina Halegoua-DeMarzio Tram Tran |
| author_sort | Dhaval Gosalia |
| collection | DOAJ |
| description | Background: The purpose of this systematic literature review (SLR) was to evaluate the accuracy of noninvasive diagnostic tools in detecting significant or advanced (F2/F3) fibrosis among patients with nonalcoholic fatty liver (NAFL) in the US healthcare context. Methods: The SLR was conducted in PubMed and Web of Science, with an additional hand search of public domains and citations, in line with the PRISMA statement. The study included US-based original research on diagnostic test sensitivity, specificity and accuracy. Results: Twenty studies were included in qualitative evidence synthesis. Imaging techniques with the highest diagnostic accuracy in F2/F3 detection and differentiation were magnetic resonance elastography and vibration-controlled transient elastography. The most promising standard blood biomarkers were NAFLD fibrosis score and FIB-4. The novel diagnostic tools showed good overall accuracy, particularly a score composed of body mass index, GGT, 25-OH-vitamin D, and platelet count. The novel approaches in liver fibrosis detection successfully combine imaging techniques and blood biomarkers. Conclusions: While noninvasive techniques could overcome some limitations of liver biopsy, a tool that would provide a sufficiently sensitive and reliable estimate of changes in fibrosis development and regression is still missing. |
| first_indexed | 2024-03-09T19:09:30Z |
| format | Article |
| id | doaj.art-8f4caca4d8a04381845feeef8e47ab69 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:09:30Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8f4caca4d8a04381845feeef8e47ab692023-11-24T04:18:01ZengMDPI AGDiagnostics2075-44182022-10-011211260810.3390/diagnostics12112608Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US StudiesDhaval Gosalia0Vlad Ratziu1Filip Stanicic2Djurdja Vukicevic3Vladimir Zah4Nadege Gunn5Dina Halegoua-DeMarzio6Tram Tran7Department of Commercial Strategy and Operations, Glympse Bio, Cambridge, MA 02140, USADepartment of Medicine, Medicine Sorbonne University, 75013 Paris, FranceHealth Economics and Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaHealth Economics and Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaHealth Economics and Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, CanadaDepartment of Hepatology, Impact Research Institute, Waco, TX 76710, USADepartment of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Medicine, UCLA Santa Monica Medical Center, Santa Monica, CA 90404, USABackground: The purpose of this systematic literature review (SLR) was to evaluate the accuracy of noninvasive diagnostic tools in detecting significant or advanced (F2/F3) fibrosis among patients with nonalcoholic fatty liver (NAFL) in the US healthcare context. Methods: The SLR was conducted in PubMed and Web of Science, with an additional hand search of public domains and citations, in line with the PRISMA statement. The study included US-based original research on diagnostic test sensitivity, specificity and accuracy. Results: Twenty studies were included in qualitative evidence synthesis. Imaging techniques with the highest diagnostic accuracy in F2/F3 detection and differentiation were magnetic resonance elastography and vibration-controlled transient elastography. The most promising standard blood biomarkers were NAFLD fibrosis score and FIB-4. The novel diagnostic tools showed good overall accuracy, particularly a score composed of body mass index, GGT, 25-OH-vitamin D, and platelet count. The novel approaches in liver fibrosis detection successfully combine imaging techniques and blood biomarkers. Conclusions: While noninvasive techniques could overcome some limitations of liver biopsy, a tool that would provide a sufficiently sensitive and reliable estimate of changes in fibrosis development and regression is still missing.https://www.mdpi.com/2075-4418/12/11/2608noninvasive diagnostic toolssensitivityspecificityliver fibrosisNAFLD |
| spellingShingle | Dhaval Gosalia Vlad Ratziu Filip Stanicic Djurdja Vukicevic Vladimir Zah Nadege Gunn Dina Halegoua-DeMarzio Tram Tran Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies Diagnostics noninvasive diagnostic tools sensitivity specificity liver fibrosis NAFLD |
| title | Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies |
| title_full | Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies |
| title_fullStr | Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies |
| title_full_unstemmed | Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies |
| title_short | Accuracy of Noninvasive Diagnostic Tests for the Detection of Significant and Advanced Fibrosis Stages in Nonalcoholic Fatty Liver Disease: A Systematic Literature Review of the US Studies |
| title_sort | accuracy of noninvasive diagnostic tests for the detection of significant and advanced fibrosis stages in nonalcoholic fatty liver disease a systematic literature review of the us studies |
| topic | noninvasive diagnostic tools sensitivity specificity liver fibrosis NAFLD |
| url | https://www.mdpi.com/2075-4418/12/11/2608 |
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