Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis
IntroductionDepression, fatigue, and anxiety are three common clinical comorbidities of multiple sclerosis (MS). We investigated the role of physical activity (PA) level and body mass index (BMI) as modifiable lifestyle factors in these three comorbidities.MethodsA cross-sectional study was conducte...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1126215/full |
| _version_ | 1797847504269606912 |
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| author | Nasim Rezaeimanesh Nasim Rezaeimanesh Pegah Rafiee Pegah Rafiee Roghayyeh Saeedi Sharareh Eskandarieh Mohammad Ali Sahraian Pegah Khosravian Maryam Abolhasani Maryam Abolhasani Soodeh Razeghi Jahromi Soodeh Razeghi Jahromi Abdorreza Naser Moghadasi |
| author_facet | Nasim Rezaeimanesh Nasim Rezaeimanesh Pegah Rafiee Pegah Rafiee Roghayyeh Saeedi Sharareh Eskandarieh Mohammad Ali Sahraian Pegah Khosravian Maryam Abolhasani Maryam Abolhasani Soodeh Razeghi Jahromi Soodeh Razeghi Jahromi Abdorreza Naser Moghadasi |
| author_sort | Nasim Rezaeimanesh |
| collection | DOAJ |
| description | IntroductionDepression, fatigue, and anxiety are three common clinical comorbidities of multiple sclerosis (MS). We investigated the role of physical activity (PA) level and body mass index (BMI) as modifiable lifestyle factors in these three comorbidities.MethodsA cross-sectional study was conducted in the MS specialist clinic of Sina Hospital, Tehran, Iran. Demographic and clinical data were collected. BMI was categorized in accordance with the WHO’s standard classification. Physical activity (PA) level and sitting time per day were obtained using the short form of the International Physical Activity Questionnaire (IPAQ-SF). Fatigue, anxiety, and depression scores were measured using the Persian version of the Fatigue Severity Scale (FSS), Beck Anxiety Inventory (BAI), and Beck’s Depression Inventory II (BDI-II) questionnaires, respectively. The correlation between the metabolic equivalent of tasks (MET), BMI, and daily sitting hours with depression, anxiety, and fatigue were checked using the linear regression test. The normal BMI group was considered a reference, and the difference in quantitative variables between the reference and the other groups was assessed using an independent sample t-test. Physical activity was classified with tertiles, and the difference in depression, anxiety, and fatigue between the PA groups was evaluated by a one-way ANOVA test.ResultsIn total, 85 MS patients were recruited for the study. The mean ± SD age of the participants was 39.07 ± 8.84 years, and 72.9% (n: 62) of them were female. The fatigue score was directly correlated with BMI (P: 0.03; r: 0.23) and sitting hours per day (P: 0.01; r: 0.26) and indirectly correlated with PA level (P < 0.01; r: −0.33). Higher depression scores were significantly correlated with elevated daily sitting hours (P: 0.01; r: 0.27). However, the correlation between depression with PA and BMI was not meaningful (p > 0.05). Higher anxiety scores were correlated with BMI (P: 0.01; r: 0.27) and lower PA (P: 0.01; r: −0.26). The correlation between anxiety and sitting hours per day was not significant (p > 0.05). Patients in the type I obesity group had significantly higher depression scores than the normal weight group (23.67 ± 2.30 vs. 14.05 ± 9.12; P: 0.001). Fatigue (32.61 ± 14.18 vs. 52.40 ± 12.42; P: <0.01) and anxiety (14.66 ± 9.68 vs. 27.80 ± 15.48; P: 0.01) scores were significantly greater among participants in the type II obesity group in comparison with the normal weight group. Fatigue (P: 0.01) and anxiety (P: 0.03) scores were significantly different in the three levels of PA, but no significant difference was found in the depression score (P: 0.17).ConclusionOur data suggest that a physically active lifestyle and being in the normal weight category are possible factors that lead to lower depression, fatigue, and anxiety in patients with MS. |
| first_indexed | 2024-04-09T18:12:34Z |
| format | Article |
| id | doaj.art-8f4ce0501e4a46f09beb804d988d64b1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T18:12:34Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-8f4ce0501e4a46f09beb804d988d64b12023-04-13T13:45:21ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11262151126215Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosisNasim Rezaeimanesh0Nasim Rezaeimanesh1Pegah Rafiee2Pegah Rafiee3Roghayyeh Saeedi4Sharareh Eskandarieh5Mohammad Ali Sahraian6Pegah Khosravian7Maryam Abolhasani8Maryam Abolhasani9Soodeh Razeghi Jahromi10Soodeh Razeghi Jahromi11Abdorreza Naser Moghadasi12Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranIntroductionDepression, fatigue, and anxiety are three common clinical comorbidities of multiple sclerosis (MS). We investigated the role of physical activity (PA) level and body mass index (BMI) as modifiable lifestyle factors in these three comorbidities.MethodsA cross-sectional study was conducted in the MS specialist clinic of Sina Hospital, Tehran, Iran. Demographic and clinical data were collected. BMI was categorized in accordance with the WHO’s standard classification. Physical activity (PA) level and sitting time per day were obtained using the short form of the International Physical Activity Questionnaire (IPAQ-SF). Fatigue, anxiety, and depression scores were measured using the Persian version of the Fatigue Severity Scale (FSS), Beck Anxiety Inventory (BAI), and Beck’s Depression Inventory II (BDI-II) questionnaires, respectively. The correlation between the metabolic equivalent of tasks (MET), BMI, and daily sitting hours with depression, anxiety, and fatigue were checked using the linear regression test. The normal BMI group was considered a reference, and the difference in quantitative variables between the reference and the other groups was assessed using an independent sample t-test. Physical activity was classified with tertiles, and the difference in depression, anxiety, and fatigue between the PA groups was evaluated by a one-way ANOVA test.ResultsIn total, 85 MS patients were recruited for the study. The mean ± SD age of the participants was 39.07 ± 8.84 years, and 72.9% (n: 62) of them were female. The fatigue score was directly correlated with BMI (P: 0.03; r: 0.23) and sitting hours per day (P: 0.01; r: 0.26) and indirectly correlated with PA level (P < 0.01; r: −0.33). Higher depression scores were significantly correlated with elevated daily sitting hours (P: 0.01; r: 0.27). However, the correlation between depression with PA and BMI was not meaningful (p > 0.05). Higher anxiety scores were correlated with BMI (P: 0.01; r: 0.27) and lower PA (P: 0.01; r: −0.26). The correlation between anxiety and sitting hours per day was not significant (p > 0.05). Patients in the type I obesity group had significantly higher depression scores than the normal weight group (23.67 ± 2.30 vs. 14.05 ± 9.12; P: 0.001). Fatigue (32.61 ± 14.18 vs. 52.40 ± 12.42; P: <0.01) and anxiety (14.66 ± 9.68 vs. 27.80 ± 15.48; P: 0.01) scores were significantly greater among participants in the type II obesity group in comparison with the normal weight group. Fatigue (P: 0.01) and anxiety (P: 0.03) scores were significantly different in the three levels of PA, but no significant difference was found in the depression score (P: 0.17).ConclusionOur data suggest that a physically active lifestyle and being in the normal weight category are possible factors that lead to lower depression, fatigue, and anxiety in patients with MS.https://www.frontiersin.org/articles/10.3389/fneur.2023.1126215/fullmultiple sclerosisfatiguedepressionanxietyphysical activitybody mass index |
| spellingShingle | Nasim Rezaeimanesh Nasim Rezaeimanesh Pegah Rafiee Pegah Rafiee Roghayyeh Saeedi Sharareh Eskandarieh Mohammad Ali Sahraian Pegah Khosravian Maryam Abolhasani Maryam Abolhasani Soodeh Razeghi Jahromi Soodeh Razeghi Jahromi Abdorreza Naser Moghadasi Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis Frontiers in Neurology multiple sclerosis fatigue depression anxiety physical activity body mass index |
| title | Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis |
| title_full | Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis |
| title_fullStr | Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis |
| title_full_unstemmed | Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis |
| title_short | Association of body mass index and physical activity with fatigue, depression, and anxiety among Iranian patients with multiple sclerosis |
| title_sort | association of body mass index and physical activity with fatigue depression and anxiety among iranian patients with multiple sclerosis |
| topic | multiple sclerosis fatigue depression anxiety physical activity body mass index |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1126215/full |
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