Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer
The consensus of endoscopic therapy for early gastric cancer (EGC) mainly depends on its clinicopathological features. However, the roles of tumor-associated neutrophils (TANs) in EGC remain uncertain. Here, we explored its predictive role for lymph node metastasis (LNM) in EGC. Three hundred twenty...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.570113/full |
| _version_ | 1818301149289119744 |
|---|---|
| author | Yaohui Wang Jing Zhai Tiancheng Zhang Shutang Han Yifen Zhang Xuequan Yao Lizong Shen |
| author_facet | Yaohui Wang Jing Zhai Tiancheng Zhang Shutang Han Yifen Zhang Xuequan Yao Lizong Shen |
| author_sort | Yaohui Wang |
| collection | DOAJ |
| description | The consensus of endoscopic therapy for early gastric cancer (EGC) mainly depends on its clinicopathological features. However, the roles of tumor-associated neutrophils (TANs) in EGC remain uncertain. Here, we explored its predictive role for lymph node metastasis (LNM) in EGC. Three hundred twenty-two patients who underwent radical gastrectomy for EGC were enrolled. Preoperative peripheral blood was used to analyze the neutrophil-to-lymphocyte ratio (NLR), and the different status of TANs was determined by hematoxylin-and-eosin staining (H&E) and immunohistochemistry (IHC). TANs, rather than NLR, were positively associated with tumor size, Lauren classification, lymphovascular invasion (LVI), and LNM. Univariate analysis revealed that TANs were associated with LNM as well as tumor size, depth of invasion, Lauren classification, histological classification, LVI, and perineural invasion. In addition to histological classification and LVI, TANs were found to be an independent risk factor for LNM in EGC (P = 0.013). Stratification analysis by depth of invasion showed LVI in SM1 tumor, and both LVI and TANs (P = 0.042) in SM2 tumor were independent risk factors for LNM. In conclusion, TANs in EGC can predict LNM, and TANs may help to estimate LNM precisely in addition to the current criteria. |
| first_indexed | 2024-12-13T05:18:25Z |
| format | Article |
| id | doaj.art-8f4d9105d49a4ddcb2218ab9d2fa3348 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T05:18:25Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8f4d9105d49a4ddcb2218ab9d2fa33482022-12-21T23:58:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.570113570113Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric CancerYaohui Wang0Jing Zhai1Tiancheng Zhang2Shutang Han3Yifen Zhang4Xuequan Yao5Lizong Shen6Department of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Surgical Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDigestive Endoscopy Center, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDigestive Endoscopy Center, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Surgical Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Surgical Oncology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaThe consensus of endoscopic therapy for early gastric cancer (EGC) mainly depends on its clinicopathological features. However, the roles of tumor-associated neutrophils (TANs) in EGC remain uncertain. Here, we explored its predictive role for lymph node metastasis (LNM) in EGC. Three hundred twenty-two patients who underwent radical gastrectomy for EGC were enrolled. Preoperative peripheral blood was used to analyze the neutrophil-to-lymphocyte ratio (NLR), and the different status of TANs was determined by hematoxylin-and-eosin staining (H&E) and immunohistochemistry (IHC). TANs, rather than NLR, were positively associated with tumor size, Lauren classification, lymphovascular invasion (LVI), and LNM. Univariate analysis revealed that TANs were associated with LNM as well as tumor size, depth of invasion, Lauren classification, histological classification, LVI, and perineural invasion. In addition to histological classification and LVI, TANs were found to be an independent risk factor for LNM in EGC (P = 0.013). Stratification analysis by depth of invasion showed LVI in SM1 tumor, and both LVI and TANs (P = 0.042) in SM2 tumor were independent risk factors for LNM. In conclusion, TANs in EGC can predict LNM, and TANs may help to estimate LNM precisely in addition to the current criteria.https://www.frontiersin.org/article/10.3389/fonc.2020.570113/fullearly gastric cancertumor-associated neutrophilslymph node metastasiscancer-associated fibroblastsIL-8 |
| spellingShingle | Yaohui Wang Jing Zhai Tiancheng Zhang Shutang Han Yifen Zhang Xuequan Yao Lizong Shen Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer Frontiers in Oncology early gastric cancer tumor-associated neutrophils lymph node metastasis cancer-associated fibroblasts IL-8 |
| title | Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer |
| title_full | Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer |
| title_fullStr | Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer |
| title_full_unstemmed | Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer |
| title_short | Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer |
| title_sort | tumor associated neutrophils can predict lymph node metastasis in early gastric cancer |
| topic | early gastric cancer tumor-associated neutrophils lymph node metastasis cancer-associated fibroblasts IL-8 |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.570113/full |
| work_keys_str_mv | AT yaohuiwang tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT jingzhai tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT tianchengzhang tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT shutanghan tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT yifenzhang tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT xuequanyao tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer AT lizongshen tumorassociatedneutrophilscanpredictlymphnodemetastasisinearlygastriccancer |