A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2019-06-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1339 |
| _version_ | 1797935191924146176 |
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| author | Jean‐François Rossignol Christian Bréchot |
| author_facet | Jean‐François Rossignol Christian Bréchot |
| author_sort | Jean‐François Rossignol |
| collection | DOAJ |
| description | Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues. |
| first_indexed | 2024-04-10T18:10:34Z |
| format | Article |
| id | doaj.art-8f4fa20270364a48b4f22ebc88cc02a0 |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-04-10T18:10:34Z |
| publishDate | 2019-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-8f4fa20270364a48b4f22ebc88cc02a02023-02-02T11:05:30ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2019-06-013674474710.1002/hep4.1339A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis BJean‐François Rossignol0Christian Bréchot1Romark Laboratories Institute of Medical Research Tampa FLRomark Laboratories Institute of Medical Research Tampa FLChronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues.https://doi.org/10.1002/hep4.1339 |
| spellingShingle | Jean‐François Rossignol Christian Bréchot A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B Hepatology Communications |
| title | A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B |
| title_full | A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B |
| title_fullStr | A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B |
| title_full_unstemmed | A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B |
| title_short | A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B |
| title_sort | pilot clinical trial of nitazoxanide in the treatment of chronic hepatitis b |
| url | https://doi.org/10.1002/hep4.1339 |
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