A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells
Conformational changes within proteins are thought to regulate clathrin-mediated endocytosis. Here, authors develop a correlative FRET and EM imaging method and uncover a structural switch in clathrin light chain that controls endocytosis in cells.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36304-7 |
| _version_ | 1811165858296233984 |
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| author | Kazuki Obashi Kem A. Sochacki Marie-Paule Strub Justin W. Taraska |
| author_facet | Kazuki Obashi Kem A. Sochacki Marie-Paule Strub Justin W. Taraska |
| author_sort | Kazuki Obashi |
| collection | DOAJ |
| description | Conformational changes within proteins are thought to regulate clathrin-mediated endocytosis. Here, authors develop a correlative FRET and EM imaging method and uncover a structural switch in clathrin light chain that controls endocytosis in cells. |
| first_indexed | 2024-04-10T15:43:20Z |
| format | Article |
| id | doaj.art-8f5004deffaa43619a844e078d9a0cbe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:43:20Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8f5004deffaa43619a844e078d9a0cbe2023-02-12T12:16:56ZengNature PortfolioNature Communications2041-17232023-02-0114111510.1038/s41467-023-36304-7A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cellsKazuki Obashi0Kem A. Sochacki1Marie-Paule Strub2Justin W. Taraska3Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of HealthBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of HealthBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of HealthBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of HealthConformational changes within proteins are thought to regulate clathrin-mediated endocytosis. Here, authors develop a correlative FRET and EM imaging method and uncover a structural switch in clathrin light chain that controls endocytosis in cells.https://doi.org/10.1038/s41467-023-36304-7 |
| spellingShingle | Kazuki Obashi Kem A. Sochacki Marie-Paule Strub Justin W. Taraska A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells Nature Communications |
| title | A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| title_full | A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| title_fullStr | A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| title_full_unstemmed | A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| title_short | A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| title_sort | conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells |
| url | https://doi.org/10.1038/s41467-023-36304-7 |
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